Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity

Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity

The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC in vivo. The present study tested whether CAP3/St14 is relevant for renal proteolytic ENaC activation and affects EN...

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Bibliographic Details
Main Authors: Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino, Yannick Jäger, Marc Maillard, Roman Szabo, Thomas H. Bugge, Simona Frateschi, Edith Hummler
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
proteolytic ENaC activation
CAP1/Prss8
CAP3/St14
sodium and potassium balance
Online Access:https://www.mdpi.com/2073-4409/12/19/2342

Internet

https://www.mdpi.com/2073-4409/12/19/2342

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