Angiorganoid: vitalizing the organoid with blood vessels
The emergence of the organoid simulates the native organs and this mini organ offers an excellent platform for probing multicellular interaction, disease modeling and drug discovery. Blood vessels constitute the instructive vascular niche which is indispensable for organ development, function and re...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2022-09-01
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| Series: | Vascular Biology |
| Subjects: | |
| Online Access: | https://vb.bioscientifica.com/view/journals/vb/4/1/VB-22-0001.xml |
| _version_ | 1818023392995966976 |
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| author | Xiaojing Ma Hongfei Li Shuntian Zhu Zixuan Hong Weijing Kong Qihang Yuan Runlong Wu Zihang Pan Jing Zhang Yahong Chen Xi Wang Kai Wang |
| author_facet | Xiaojing Ma Hongfei Li Shuntian Zhu Zixuan Hong Weijing Kong Qihang Yuan Runlong Wu Zihang Pan Jing Zhang Yahong Chen Xi Wang Kai Wang |
| author_sort | Xiaojing Ma |
| collection | DOAJ |
| description | The emergence of the organoid simulates the native organs and this mini organ offers an excellent platform for probing multicellular interaction, disease modeling and drug discovery. Blood vessels constitute the instructive vascular niche which is indispensable for organ development, function and regeneration. Therefore, it is expected that the introduction of infiltrated blood vessels into the organoid might further pump vitality and credibility into the system. While the field is emerging and growing with new concepts and methodologies, this review aims at presenting various sources of vascular ingredients for constructing vascularized organoids and the paired methodology including de- and recellularization, bioprinting and microfluidics. Representative vascular organoids corresponding to specific tissues are also summarized and discussed to elaborate on the next generation of organoid development. |
| first_indexed | 2024-12-10T03:43:36Z |
| format | Article |
| id | doaj.art-c6b65cdfa36e41f7a12a0aeafe5ce78f |
| institution | Directory Open Access Journal |
| issn | 2516-5658 |
| language | English |
| last_indexed | 2024-12-10T03:43:36Z |
| publishDate | 2022-09-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Vascular Biology |
| spelling | doaj.art-c6b65cdfa36e41f7a12a0aeafe5ce78f2022-12-22T02:03:31ZengBioscientificaVascular Biology2516-56582022-09-0141R44R57https://doi.org/10.1530/VB-22-0001Angiorganoid: vitalizing the organoid with blood vesselsXiaojing Ma0Hongfei Li1Shuntian Zhu2Zixuan Hong3Weijing Kong4Qihang Yuan5Runlong Wu6Zihang Pan7Jing Zhang8Yahong Chen9Xi Wang10Kai Wang11Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts, USADepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, ChinaDepartment of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, ChinaDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USADepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China The emergence of the organoid simulates the native organs and this mini organ offers an excellent platform for probing multicellular interaction, disease modeling and drug discovery. Blood vessels constitute the instructive vascular niche which is indispensable for organ development, function and regeneration. Therefore, it is expected that the introduction of infiltrated blood vessels into the organoid might further pump vitality and credibility into the system. While the field is emerging and growing with new concepts and methodologies, this review aims at presenting various sources of vascular ingredients for constructing vascularized organoids and the paired methodology including de- and recellularization, bioprinting and microfluidics. Representative vascular organoids corresponding to specific tissues are also summarized and discussed to elaborate on the next generation of organoid development.https://vb.bioscientifica.com/view/journals/vb/4/1/VB-22-0001.xmlblood vesselsangiorganoidorganoidbioengineering |
| spellingShingle | Xiaojing Ma Hongfei Li Shuntian Zhu Zixuan Hong Weijing Kong Qihang Yuan Runlong Wu Zihang Pan Jing Zhang Yahong Chen Xi Wang Kai Wang Angiorganoid: vitalizing the organoid with blood vessels Vascular Biology blood vessels angiorganoid organoid bioengineering |
| title | Angiorganoid: vitalizing the organoid with blood vessels |
| title_full | Angiorganoid: vitalizing the organoid with blood vessels |
| title_fullStr | Angiorganoid: vitalizing the organoid with blood vessels |
| title_full_unstemmed | Angiorganoid: vitalizing the organoid with blood vessels |
| title_short | Angiorganoid: vitalizing the organoid with blood vessels |
| title_sort | angiorganoid vitalizing the organoid with blood vessels |
| topic | blood vessels angiorganoid organoid bioengineering |
| url | https://vb.bioscientifica.com/view/journals/vb/4/1/VB-22-0001.xml |
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