Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma
Asthma is a chronic inflammatory airway disease characterized by reversible airway obstruction and airway hyperreactivity. We proposed a cold dry air (CDA) provocation test and investigated its application in pediatric patients with asthma. We enrolled 72 children and adolescents older than 5 years...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/6/920 |
| _version_ | 1797488738966700032 |
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| author | Ji Young Ahn Bong Seok Choi |
| author_facet | Ji Young Ahn Bong Seok Choi |
| author_sort | Ji Young Ahn |
| collection | DOAJ |
| description | Asthma is a chronic inflammatory airway disease characterized by reversible airway obstruction and airway hyperreactivity. We proposed a cold dry air (CDA) provocation test and investigated its application in pediatric patients with asthma. We enrolled 72 children and adolescents older than 5 years who presented to our hospital with chronic cough, shortness of breath, and wheezing. We analyzed the results of allergy, pulmonary function, methacholine provocation, and CDA provocation tests. The FEV1 change 5 min after the provocation was recorded as CDA5 dFEV1; that after 15 min was recorded as CDA15 dFEV1. PT10 was the provocation time causing a 10% decrease in FEV1; a decrease of >10% in dFEV1 was considered a positive CDA test. Among the 72 subjects, 51 were diagnosed with asthma. A positive CDA test in patients with asthma correlated with non-eosinophilic asthma. In patients with asthma, sputum eosinophils and eosinophil cationic protein (ECP) levels of the patients with a positive CDA test were significantly lower than those of patients with a negative test. CDA5 dFEV1 correlated with PC20 and total immunoglobulin E. CDA15 dFEV1 correlated with PC20, sputum eosinophils, and ECP. PT10 became shorter as the peripheral blood eosinophil, FVC, FEV1, FEV1/FVC, and FEF25-75 decreased. The CDA provocation test showed airway hyperreactivity to non-specific stimuli, a high correlation with non-eosinophilic asthma, and the possibility of assessing asthma severity via PT10. |
| first_indexed | 2024-03-10T00:07:33Z |
| format | Article |
| id | doaj.art-c6b7a2d7b49d40e9b34252e046e080ec |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T00:07:33Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-c6b7a2d7b49d40e9b34252e046e080ec2023-11-23T16:07:02ZengMDPI AGChildren2227-90672022-06-019692010.3390/children9060920Application of a Cold Dry Air Provocation Test in Pediatric Patients with AsthmaJi Young Ahn0Bong Seok Choi1Department of Pediatrics, College of Medicine, Yeungnam University, Daegu 42415, KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, KoreaAsthma is a chronic inflammatory airway disease characterized by reversible airway obstruction and airway hyperreactivity. We proposed a cold dry air (CDA) provocation test and investigated its application in pediatric patients with asthma. We enrolled 72 children and adolescents older than 5 years who presented to our hospital with chronic cough, shortness of breath, and wheezing. We analyzed the results of allergy, pulmonary function, methacholine provocation, and CDA provocation tests. The FEV1 change 5 min after the provocation was recorded as CDA5 dFEV1; that after 15 min was recorded as CDA15 dFEV1. PT10 was the provocation time causing a 10% decrease in FEV1; a decrease of >10% in dFEV1 was considered a positive CDA test. Among the 72 subjects, 51 were diagnosed with asthma. A positive CDA test in patients with asthma correlated with non-eosinophilic asthma. In patients with asthma, sputum eosinophils and eosinophil cationic protein (ECP) levels of the patients with a positive CDA test were significantly lower than those of patients with a negative test. CDA5 dFEV1 correlated with PC20 and total immunoglobulin E. CDA15 dFEV1 correlated with PC20, sputum eosinophils, and ECP. PT10 became shorter as the peripheral blood eosinophil, FVC, FEV1, FEV1/FVC, and FEF25-75 decreased. The CDA provocation test showed airway hyperreactivity to non-specific stimuli, a high correlation with non-eosinophilic asthma, and the possibility of assessing asthma severity via PT10.https://www.mdpi.com/2227-9067/9/6/920asthmacold dry air provocationchronic inflammatory airway diseasechild |
| spellingShingle | Ji Young Ahn Bong Seok Choi Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma Children asthma cold dry air provocation chronic inflammatory airway disease child |
| title | Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma |
| title_full | Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma |
| title_fullStr | Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma |
| title_full_unstemmed | Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma |
| title_short | Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma |
| title_sort | application of a cold dry air provocation test in pediatric patients with asthma |
| topic | asthma cold dry air provocation chronic inflammatory airway disease child |
| url | https://www.mdpi.com/2227-9067/9/6/920 |
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