Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization
Onychomycosis constitutes the most common fungal infection of nail affecting finger and toe nails as well. Antifungals found to be effective in the treatment of onychomycosis. However, transport of oral antifungal agents exhibits more toxicity and requires longer treatment period. Medicated nail lac...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2016-09-01
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| Series: | Pharmaceutical and Biomedical Research |
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| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-5&slc_lang=en&sid=1 |
| _version_ | 1831636165469405184 |
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| author | Nida Akhtar Soniya Sahu Kamla Pathak |
| author_facet | Nida Akhtar Soniya Sahu Kamla Pathak |
| author_sort | Nida Akhtar |
| collection | DOAJ |
| description | Onychomycosis constitutes the most common fungal infection of nail affecting finger and toe nails as well. Antifungals found to be effective in the treatment of onychomycosis. However, transport of oral antifungal agents exhibits more toxicity and requires longer treatment period. Medicated nail lacquers proved to cause lesser toxicity and required shorter treatment period. It provides not only finger/toe nail infection therapy and but also act as a protection for nails. Thus, the objective behind the present investigation was to develop nail lacquer for transungual delivery of tolnaftate. Its potency had been assessed by evaluating penetration efficiency across the bovine hoof membrane. Preliminary studies aided the optimization of thioglycolic acid as permeation enhancer (HEFmax 0.60 ± 0.377) and menthol as local anaesthetic. n-butanol:isopropyl alcohol with optimum drying time of 60 sec was selected as optimum solvent system. In total nine formulations were developed based on 32 full factorial design and characterized for drying time, non-volatile content, in vitro adhesion and permeation study. Based on highest desirability, F6 was selected as an optimized formulation and evaluated for viscosity, stability and antifungal activity. Optimized formulation exhibited optimum viscosity and stability for 1 month period. Better antifungal activity was observed against Candida albicans in comparison to the control formulation. Thus, it can be concluded from the investigation that nail lacquer could proved to be a better alternative for transungual delivery of tolnaftate. |
| first_indexed | 2024-12-19T06:28:14Z |
| format | Article |
| id | doaj.art-c6b7c525a4504523bd2c4469d85004dc |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-19T06:28:14Z |
| publishDate | 2016-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-c6b7c525a4504523bd2c4469d85004dc2022-12-21T20:32:28ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942016-09-0123112Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterizationNida Akhtar0Soniya Sahu1Kamla Pathak2 Department of Pharmaceutics, Rajiv Academy for Pharmacy, P.O. Chhatikara, Mathura- 281001, Uttar Pradesh, India Department of Pharmaceutics, Rajiv Academy for Pharmacy, P.O. Chhatikara, Mathura- 281001, Uttar Pradesh, India Department of Pharmaceutics, Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Saifai, Etawah-206130, Uttar Pradesh, India. Onychomycosis constitutes the most common fungal infection of nail affecting finger and toe nails as well. Antifungals found to be effective in the treatment of onychomycosis. However, transport of oral antifungal agents exhibits more toxicity and requires longer treatment period. Medicated nail lacquers proved to cause lesser toxicity and required shorter treatment period. It provides not only finger/toe nail infection therapy and but also act as a protection for nails. Thus, the objective behind the present investigation was to develop nail lacquer for transungual delivery of tolnaftate. Its potency had been assessed by evaluating penetration efficiency across the bovine hoof membrane. Preliminary studies aided the optimization of thioglycolic acid as permeation enhancer (HEFmax 0.60 ± 0.377) and menthol as local anaesthetic. n-butanol:isopropyl alcohol with optimum drying time of 60 sec was selected as optimum solvent system. In total nine formulations were developed based on 32 full factorial design and characterized for drying time, non-volatile content, in vitro adhesion and permeation study. Based on highest desirability, F6 was selected as an optimized formulation and evaluated for viscosity, stability and antifungal activity. Optimized formulation exhibited optimum viscosity and stability for 1 month period. Better antifungal activity was observed against Candida albicans in comparison to the control formulation. Thus, it can be concluded from the investigation that nail lacquer could proved to be a better alternative for transungual delivery of tolnaftate.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-5&slc_lang=en&sid=1Bovine hoof Candida albicans fungal infection onychomycosis penetration transungual |
| spellingShingle | Nida Akhtar Soniya Sahu Kamla Pathak Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization Pharmaceutical and Biomedical Research Bovine hoof Candida albicans fungal infection onychomycosis penetration transungual |
| title | Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization |
| title_full | Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization |
| title_fullStr | Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization |
| title_full_unstemmed | Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization |
| title_short | Antifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization |
| title_sort | antifungal potential of tolnaftate against candida albicans in the treatment of onychomycosis development of nail lacquer and ex vivo characterization |
| topic | Bovine hoof Candida albicans fungal infection onychomycosis penetration transungual |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-5&slc_lang=en&sid=1 |
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