Inositol 1,4,5‐Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation

Inositol 1,4,5‐Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation

Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca2+ mobilization is a critical modulator of endothelial NO synthase function, and increased cytosolic Ca2+ concentration in endothelial cells is able to induce endothelial NO synthas...

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Bibliographic Details
Main Authors: Qingsong Lin, Lingyun Zhao, Ran Jing, Christa Trexler, Hong Wang, Yali Li, Huayuan Tang, Fang Huang, Fei Zhang, Xi Fang, Jie Liu, Nan Jia, Ju Chen, Kunfu Ouyang
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
blood pressure
calcium
calcium signaling
endothelial cell
hypertension
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.011704

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