Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states
In the second part we present a review of the existing data about ability of integrated tests, as already introduced in clinical practice, and the new (test of thrombin generation, thromboelastography, thrombodynamics, perfusion chamber) to assess the risk of thrombosis in different pathologies. We...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-10-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/158 |
| _version_ | 1797855563600625664 |
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| author | E. N. Lipets F. I. Ataullakhanov M. A. Panteleev |
| author_facet | E. N. Lipets F. I. Ataullakhanov M. A. Panteleev |
| author_sort | E. N. Lipets |
| collection | DOAJ |
| description | In the second part we present a review of the existing data about ability of integrated tests, as already introduced in clinical practice, and the new (test of thrombin generation, thromboelastography, thrombodynamics, perfusion chamber) to assess the risk of thrombosis in different pathologies. We can conclude that the existing integrated tests can be an important tool in the diagnosis of hypercoagulation. However, lack of standardization prevents their use: various tests and modifications of each test are different in sensitivity and specificity for each pathological condition. Furthermore, even in situations where the tests can reliably identify a group of patients with different degrees of thrombosis risk, their use in clinical practice is often difficult, since the differences between these groups were statistically significant, but the normal range and patients significantly overlap. |
| first_indexed | 2024-04-09T20:25:51Z |
| format | Article |
| id | doaj.art-c6b83fe7e5bb43c7a3e3c7f6177e8335 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:25:51Z |
| publishDate | 2015-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-c6b83fe7e5bb43c7a3e3c7f6177e83352023-03-30T20:15:11ZrusABV-pressОнкогематология1818-83462413-40232015-10-01103789110.17650/1818-8346-2015-10-3-78-91172Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable statesE. N. Lipets0F. I. Ataullakhanov1M. A. Panteleev2Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev; Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of SciencesFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev; Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences; HemaCore Company; M.V. Lomonosov Moscow State UniversityFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev; Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences; HemaCore Company; M.V. Lomonosov Moscow State UniversityIn the second part we present a review of the existing data about ability of integrated tests, as already introduced in clinical practice, and the new (test of thrombin generation, thromboelastography, thrombodynamics, perfusion chamber) to assess the risk of thrombosis in different pathologies. We can conclude that the existing integrated tests can be an important tool in the diagnosis of hypercoagulation. However, lack of standardization prevents their use: various tests and modifications of each test are different in sensitivity and specificity for each pathological condition. Furthermore, even in situations where the tests can reliably identify a group of patients with different degrees of thrombosis risk, their use in clinical practice is often difficult, since the differences between these groups were statistically significant, but the normal range and patients significantly overlap.https://oncohematology.abvpress.ru/ongm/article/view/158global assays of hemostasishypercoagulationthrombosisactivated partial thromboplastin timethrombin generationthrombelastographythrombodynamicscancerpregnancydiabetes mellitus |
| spellingShingle | E. N. Lipets F. I. Ataullakhanov M. A. Panteleev Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states Онкогематология global assays of hemostasis hypercoagulation thrombosis activated partial thromboplastin time thrombin generation thrombelastography thrombodynamics cancer pregnancy diabetes mellitus |
| title | Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states |
| title_full | Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states |
| title_fullStr | Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states |
| title_full_unstemmed | Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states |
| title_short | Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable states |
| title_sort | integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment part ii the sensitivity of integral tests to hypercoagulable states |
| topic | global assays of hemostasis hypercoagulation thrombosis activated partial thromboplastin time thrombin generation thrombelastography thrombodynamics cancer pregnancy diabetes mellitus |
| url | https://oncohematology.abvpress.ru/ongm/article/view/158 |
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