The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions.
In addition to rods and cones, photoreception in mammals extends to a third retinal cell type expressing the photopigment melanopsin. The influences of this novel opsin are widespread, ranging from pupillary and circadian responses to brightness perception, yet established approaches to quantifying...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3536742?pdf=render |
| _version_ | 1819113317195579392 |
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| author | Timothy M Brown Annette E Allen Jazi al-Enezi Jonathan Wynne Luc Schlangen Vanja Hommes Robert J Lucas |
| author_facet | Timothy M Brown Annette E Allen Jazi al-Enezi Jonathan Wynne Luc Schlangen Vanja Hommes Robert J Lucas |
| author_sort | Timothy M Brown |
| collection | DOAJ |
| description | In addition to rods and cones, photoreception in mammals extends to a third retinal cell type expressing the photopigment melanopsin. The influences of this novel opsin are widespread, ranging from pupillary and circadian responses to brightness perception, yet established approaches to quantifying the biological effects of light do not adequately account for melanopsin sensitivity. We have recently proposed a novel metric, the melanopic sensitivity function (V(Z)λ), to address this deficiency. Here, we further validate this new measure with a variety of tests based on potential barriers to its applicability identified in the literature or relating to obvious practical benefits. Using electrophysiogical approaches and pupillometry, initially in rodless+coneless mice, our data demonstrate that under a very wide range of different conditions (including switching between stimuli with highly divergent spectral content) the V(Z)λ function provides an accurate prediction of the sensitivity of melanopsin-dependent responses. We further show that V(Z)λ provides the best available description of the spectral sensitivity of at least one aspect of the visual response in mice with functional rods and cones: tonic firing activity in the lateral geniculate nuclei. Together, these data establish V(Z)λ as an important new approach for light measurement with widespread practical utility. |
| first_indexed | 2024-12-22T04:27:29Z |
| format | Article |
| id | doaj.art-c6b86afb4c94431996d7823d818d5228 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T04:27:29Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c6b86afb4c94431996d7823d818d52282022-12-21T18:39:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5358310.1371/journal.pone.0053583The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions.Timothy M BrownAnnette E AllenJazi al-EneziJonathan WynneLuc SchlangenVanja HommesRobert J LucasIn addition to rods and cones, photoreception in mammals extends to a third retinal cell type expressing the photopigment melanopsin. The influences of this novel opsin are widespread, ranging from pupillary and circadian responses to brightness perception, yet established approaches to quantifying the biological effects of light do not adequately account for melanopsin sensitivity. We have recently proposed a novel metric, the melanopic sensitivity function (V(Z)λ), to address this deficiency. Here, we further validate this new measure with a variety of tests based on potential barriers to its applicability identified in the literature or relating to obvious practical benefits. Using electrophysiogical approaches and pupillometry, initially in rodless+coneless mice, our data demonstrate that under a very wide range of different conditions (including switching between stimuli with highly divergent spectral content) the V(Z)λ function provides an accurate prediction of the sensitivity of melanopsin-dependent responses. We further show that V(Z)λ provides the best available description of the spectral sensitivity of at least one aspect of the visual response in mice with functional rods and cones: tonic firing activity in the lateral geniculate nuclei. Together, these data establish V(Z)λ as an important new approach for light measurement with widespread practical utility.http://europepmc.org/articles/PMC3536742?pdf=render |
| spellingShingle | Timothy M Brown Annette E Allen Jazi al-Enezi Jonathan Wynne Luc Schlangen Vanja Hommes Robert J Lucas The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions. PLoS ONE |
| title | The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions. |
| title_full | The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions. |
| title_fullStr | The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions. |
| title_full_unstemmed | The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions. |
| title_short | The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditions. |
| title_sort | melanopic sensitivity function accounts for melanopsin driven responses in mice under diverse lighting conditions |
| url | http://europepmc.org/articles/PMC3536742?pdf=render |
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