Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis
BackgroundPatients on hemodialysis have a higher burden of cognitive impairment than individuals of the same age in the general population. Studies have found a link between cognition and skeletal muscle function. However, few studies have investigated these associations and the underlying mechanism...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1324867/full |
| _version_ | 1797261800899608576 |
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| author | Lulu Wang Xueqin Bian Lilin Liu Qingyun He Jie Xu Xue Chen Hong Ye Junwei Yang Lei Jiang |
| author_facet | Lulu Wang Xueqin Bian Lilin Liu Qingyun He Jie Xu Xue Chen Hong Ye Junwei Yang Lei Jiang |
| author_sort | Lulu Wang |
| collection | DOAJ |
| description | BackgroundPatients on hemodialysis have a higher burden of cognitive impairment than individuals of the same age in the general population. Studies have found a link between cognition and skeletal muscle function. However, few studies have investigated these associations and the underlying mechanisms in patients on hemodialysis.MethodsA total of 166 patients on hemodialysis were enrolled in this longitudinal study. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) scores. Skeletal muscle indicators were evaluated using Inbody S10. Plasma brain-derived neurotrophic factor (BDNF) concentrations were measured by enzyme-linked immunosorbent assay. The primary outcome was a change in the MoCA scores. A mediation analysis was performed to examine the indirect effect of skeletal muscle on cognitive decline through BDNF.ResultsAmong the 166 patients, the average age was 49.9 ± 11.2 years. Of these patients with a median follow-up of 1,136 days, 133 participated in the study. We defined MoCA scores decreased by ≥2 points at 3 years from the baseline measurement as cognitive decline (CD). Compared to the cognitively unchanged group, patients with CD had significantly lower fat-free mass, soft lean mass, skeletal muscle mass, and skeletal muscle index (all P<0.05). After adjusting for potential confounders, skeletal muscle indicators were protective predictors of CD. A significant increase in plasma BDNF levels was observed in the CD group. Mediation analysis suggested that BDNF played a mediating role of 20-35% between cognitive impairment and skeletal muscle.ConclusionSkeletal muscle is a protective predictor of CD in patients undergoing dialysis. BDNF mediates the relationship between cognitive impairment and skeletal muscle function. |
| first_indexed | 2024-04-24T23:46:59Z |
| format | Article |
| id | doaj.art-c6b9611cb99c40e788fccba5b541bb36 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T23:46:59Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c6b9611cb99c40e788fccba5b541bb362024-03-15T04:57:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13248671324867Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysisLulu WangXueqin BianLilin LiuQingyun HeJie XuXue ChenHong YeJunwei YangLei JiangBackgroundPatients on hemodialysis have a higher burden of cognitive impairment than individuals of the same age in the general population. Studies have found a link between cognition and skeletal muscle function. However, few studies have investigated these associations and the underlying mechanisms in patients on hemodialysis.MethodsA total of 166 patients on hemodialysis were enrolled in this longitudinal study. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) scores. Skeletal muscle indicators were evaluated using Inbody S10. Plasma brain-derived neurotrophic factor (BDNF) concentrations were measured by enzyme-linked immunosorbent assay. The primary outcome was a change in the MoCA scores. A mediation analysis was performed to examine the indirect effect of skeletal muscle on cognitive decline through BDNF.ResultsAmong the 166 patients, the average age was 49.9 ± 11.2 years. Of these patients with a median follow-up of 1,136 days, 133 participated in the study. We defined MoCA scores decreased by ≥2 points at 3 years from the baseline measurement as cognitive decline (CD). Compared to the cognitively unchanged group, patients with CD had significantly lower fat-free mass, soft lean mass, skeletal muscle mass, and skeletal muscle index (all P<0.05). After adjusting for potential confounders, skeletal muscle indicators were protective predictors of CD. A significant increase in plasma BDNF levels was observed in the CD group. Mediation analysis suggested that BDNF played a mediating role of 20-35% between cognitive impairment and skeletal muscle.ConclusionSkeletal muscle is a protective predictor of CD in patients undergoing dialysis. BDNF mediates the relationship between cognitive impairment and skeletal muscle function.https://www.frontiersin.org/articles/10.3389/fendo.2024.1324867/fullcognitive functionskeletal muscleBDNFhemodialysisMoCA |
| spellingShingle | Lulu Wang Xueqin Bian Lilin Liu Qingyun He Jie Xu Xue Chen Hong Ye Junwei Yang Lei Jiang Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis Frontiers in Endocrinology cognitive function skeletal muscle BDNF hemodialysis MoCA |
| title | Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis |
| title_full | Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis |
| title_fullStr | Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis |
| title_full_unstemmed | Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis |
| title_short | Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis |
| title_sort | association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis |
| topic | cognitive function skeletal muscle BDNF hemodialysis MoCA |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1324867/full |
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