A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging
Abstract Background As recovery time of diabetic wound injury is prolonged by the production of detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating the oxidative stress and inflammatory reactions in the microenvironment of the diabetic wound site woul...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-12-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01151-5 |
| _version_ | 1818008089862864896 |
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| author | Yao Qi Kun Qian Jin Chen Yifeng E Yijie Shi Hongdan Li Liang Zhao |
| author_facet | Yao Qi Kun Qian Jin Chen Yifeng E Yijie Shi Hongdan Li Liang Zhao |
| author_sort | Yao Qi |
| collection | DOAJ |
| description | Abstract Background As recovery time of diabetic wound injury is prolonged by the production of detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating the oxidative stress and inflammatory reactions in the microenvironment of the diabetic wound site would be significant. Experimental design In our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote diabetic wound healing via the neutralization of detrimental factors such as inflammatory cytokines and ROS. Results The cerium (Ce)-doped biotype Linde type A (LTA) zeolite nanoparticles synergistically eliminated mitochondrial ROS and neutralized free inflammatory factors, thus remodeling the anti-inflammatory microenvironment of the wound and enhancing angiogenesis. Moreover, the thermoreversible hydrogel composed of Pluronic F127 and chitosan demonstrated strong haemostatic and bactericidal behavior. Conclusions In conclusion, the obtained thermoreversible, antibacterial, zeolite-based nanoparticles loaded hydrogels represent a multi-targeted combination therapy for diabetic wound healing. Graphical Abstract |
| first_indexed | 2024-04-14T05:24:45Z |
| format | Article |
| id | doaj.art-c6b9b1c7a58f4dc0a4db285c34901374 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T05:24:45Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-c6b9b1c7a58f4dc0a4db285c349013742022-12-22T02:10:01ZengBMCJournal of Nanobiotechnology1477-31552021-12-0119112010.1186/s12951-021-01151-5A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavengingYao Qi0Kun Qian1Jin Chen2Yifeng E3Yijie Shi4Hongdan Li5Liang Zhao6School of Pharmacy, Jinzhou Medical UniversityDepartment of Chemistry, Jinzhou Medical UniversitySchool of Pharmacy, Jinzhou Medical UniversitySchool of Pharmacy, Jinzhou Medical UniversitySchool of Pharmacy, Jinzhou Medical UniversityLife Science Institute, Jinzhou Medical UniversitySchool of Pharmacy, Jinzhou Medical UniversityAbstract Background As recovery time of diabetic wound injury is prolonged by the production of detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating the oxidative stress and inflammatory reactions in the microenvironment of the diabetic wound site would be significant. Experimental design In our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote diabetic wound healing via the neutralization of detrimental factors such as inflammatory cytokines and ROS. Results The cerium (Ce)-doped biotype Linde type A (LTA) zeolite nanoparticles synergistically eliminated mitochondrial ROS and neutralized free inflammatory factors, thus remodeling the anti-inflammatory microenvironment of the wound and enhancing angiogenesis. Moreover, the thermoreversible hydrogel composed of Pluronic F127 and chitosan demonstrated strong haemostatic and bactericidal behavior. Conclusions In conclusion, the obtained thermoreversible, antibacterial, zeolite-based nanoparticles loaded hydrogels represent a multi-targeted combination therapy for diabetic wound healing. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01151-5Reactive oxygen speciesZeoliteHydrogelPluronic F127Chitosan |
| spellingShingle | Yao Qi Kun Qian Jin Chen Yifeng E Yijie Shi Hongdan Li Liang Zhao A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging Journal of Nanobiotechnology Reactive oxygen species Zeolite Hydrogel Pluronic F127 Chitosan |
| title | A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging |
| title_full | A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging |
| title_fullStr | A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging |
| title_full_unstemmed | A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging |
| title_short | A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging |
| title_sort | thermoreversible antibacterial zeolite based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ros scavenging |
| topic | Reactive oxygen species Zeolite Hydrogel Pluronic F127 Chitosan |
| url | https://doi.org/10.1186/s12951-021-01151-5 |
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