The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted thera...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.800140/full |
| _version_ | 1811233900329959424 |
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| author | Weigang Gu HongZhang Shen Lu Xie Xiaofeng Zhang Xiaofeng Zhang Jianfeng Yang |
| author_facet | Weigang Gu HongZhang Shen Lu Xie Xiaofeng Zhang Xiaofeng Zhang Jianfeng Yang |
| author_sort | Weigang Gu |
| collection | DOAJ |
| description | Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted therapy drugs. Numerous studies have associated feedback loop regulation with the development and therapeutic response of cancers including pancreatic cancer. Therefore, we review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment, highlighting the potential of capitalizing on feedback loops modulation in targeted therapy for pancreatic cancer. |
| first_indexed | 2024-04-12T11:26:56Z |
| format | Article |
| id | doaj.art-c6bc4d0d9d994378a2d36d39040d9eb3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T11:26:56Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c6bc4d0d9d994378a2d36d39040d9eb32022-12-22T03:35:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.800140800140The Role of Feedback Loops in Targeted Therapy for Pancreatic CancerWeigang Gu0HongZhang Shen1Lu Xie2Xiaofeng Zhang3Xiaofeng Zhang4Jianfeng Yang5Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaKey Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, ChinaDepartment of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaPancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted therapy drugs. Numerous studies have associated feedback loop regulation with the development and therapeutic response of cancers including pancreatic cancer. Therefore, we review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment, highlighting the potential of capitalizing on feedback loops modulation in targeted therapy for pancreatic cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.800140/fullpancreatic cancerfeedback loopstargeted therapynegative regulationpositive regulation |
| spellingShingle | Weigang Gu HongZhang Shen Lu Xie Xiaofeng Zhang Xiaofeng Zhang Jianfeng Yang The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer Frontiers in Oncology pancreatic cancer feedback loops targeted therapy negative regulation positive regulation |
| title | The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer |
| title_full | The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer |
| title_fullStr | The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer |
| title_full_unstemmed | The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer |
| title_short | The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer |
| title_sort | role of feedback loops in targeted therapy for pancreatic cancer |
| topic | pancreatic cancer feedback loops targeted therapy negative regulation positive regulation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.800140/full |
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