Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias
Objective Unclassifiable interstitial lung disease (ILD) is a common problem in clinical practice. These patients pose a distinct challenge with regard to appropriate evaluation and management. We investigated the clinical features and prognosis of unclassifiable ILD and compared its clinical profil...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-01-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060517719767 |
| _version_ | 1819041807128854528 |
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| author | Daniel Traila Cristian Oancea Emanuela Tudorache Ovidiu Fira Mladinescu Bogdan Timar Voicu Tudorache |
| author_facet | Daniel Traila Cristian Oancea Emanuela Tudorache Ovidiu Fira Mladinescu Bogdan Timar Voicu Tudorache |
| author_sort | Daniel Traila |
| collection | DOAJ |
| description | Objective Unclassifiable interstitial lung disease (ILD) is a common problem in clinical practice. These patients pose a distinct challenge with regard to appropriate evaluation and management. We investigated the clinical features and prognosis of unclassifiable ILD and compared its clinical profile with that of idiopathic pulmonary fibrosis (IPF) and idiopathic nonspecific interstitial pneumonia (NSIP). Methods Patients with IPF (n = 40), NSIP (n = 14), and unclassifiable ILD (n = 27) were selected from an ongoing database. Baseline clinical features, pulmonary function, and the extent of fibrosis on high-resolution computed tomography (HRCT) were evaluated. Mortality was estimated based on the ILD–Gender, Age, Physiology (ILD-GAP) index and composite physiologic index (CPI). Results IPF was associated with the worst survival (hazard ratio [HR] = 4.361 compared with NSIP), followed by unclassifiable cases (HR = 1.251 compared with NSIP). Increasing mortality was significantly impacted by age (HR = 1.04 per 1-year increase), lower carbon monoxide diffusing capacity of the lung (HR = 0.97), HRCT interstitial score (HR = 1.119 per 1-point increase), ILD-GAP score (HR = 1.570 per 1-point increase), and CPI (HR = 1.039 per 1-point increase). Conclusions Patients with unclassifiable ILD had an intermediate prognosis between that of IPF and NSIP. Patients at high risk of mortality can be identified using baseline clinical, physiological, and radiological features. |
| first_indexed | 2024-12-21T09:30:51Z |
| format | Article |
| id | doaj.art-c6be1a80b74d4fb6a1a6d46ecaddc5aa |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T09:30:51Z |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-c6be1a80b74d4fb6a1a6d46ecaddc5aa2022-12-21T19:08:46ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002018-01-014610.1177/0300060517719767Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumoniasDaniel Traila0Cristian Oancea1Emanuela Tudorache2Ovidiu Fira Mladinescu3Bogdan Timar4Voicu Tudorache5Department of Pulmonary Medicine, University of Medicine and Pharmacy “Victor Babes,” Timisoara, RomâniaDepartment of Pulmonary Medicine, University of Medicine and Pharmacy “Victor Babes,” Timisoara, RomâniaDepartment of Pulmonary Medicine, University of Medicine and Pharmacy “Victor Babes,” Timisoara, RomâniaDepartment of Pulmonary Medicine, University of Medicine and Pharmacy “Victor Babes,” Timisoara, RomâniaDepartment of Biostatistics and Medical Informatics, University of Medicine and Pharmacy “Victor Babes,” Timisoara, RomâniaDepartment of Pulmonary Medicine, University of Medicine and Pharmacy “Victor Babes,” Timisoara, RomâniaObjective Unclassifiable interstitial lung disease (ILD) is a common problem in clinical practice. These patients pose a distinct challenge with regard to appropriate evaluation and management. We investigated the clinical features and prognosis of unclassifiable ILD and compared its clinical profile with that of idiopathic pulmonary fibrosis (IPF) and idiopathic nonspecific interstitial pneumonia (NSIP). Methods Patients with IPF (n = 40), NSIP (n = 14), and unclassifiable ILD (n = 27) were selected from an ongoing database. Baseline clinical features, pulmonary function, and the extent of fibrosis on high-resolution computed tomography (HRCT) were evaluated. Mortality was estimated based on the ILD–Gender, Age, Physiology (ILD-GAP) index and composite physiologic index (CPI). Results IPF was associated with the worst survival (hazard ratio [HR] = 4.361 compared with NSIP), followed by unclassifiable cases (HR = 1.251 compared with NSIP). Increasing mortality was significantly impacted by age (HR = 1.04 per 1-year increase), lower carbon monoxide diffusing capacity of the lung (HR = 0.97), HRCT interstitial score (HR = 1.119 per 1-point increase), ILD-GAP score (HR = 1.570 per 1-point increase), and CPI (HR = 1.039 per 1-point increase). Conclusions Patients with unclassifiable ILD had an intermediate prognosis between that of IPF and NSIP. Patients at high risk of mortality can be identified using baseline clinical, physiological, and radiological features.https://doi.org/10.1177/0300060517719767 |
| spellingShingle | Daniel Traila Cristian Oancea Emanuela Tudorache Ovidiu Fira Mladinescu Bogdan Timar Voicu Tudorache Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias Journal of International Medical Research |
| title | Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias |
| title_full | Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias |
| title_fullStr | Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias |
| title_full_unstemmed | Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias |
| title_short | Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias |
| title_sort | clinical profile of unclassifiable interstitial lung disease comparison with chronic fibrosing idiopathic interstitial pneumonias |
| url | https://doi.org/10.1177/0300060517719767 |
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