Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells.

Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells.

Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are required for persistent migration and chemotaxis, but how they affect cell polarity is not known.Here we report that T cells treated with nocodazol...

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Bibliographic Details
Main Authors: Aya Takesono, Sarah J Heasman, Beata Wojciak-Stothard, Ritu Garg, Anne J Ridley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2808253?pdf=render

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