Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis
Introduction. Trichomoniasis is a vaginal infectious and inflammatory disease, which falls into the category of sexually transmissible nosological entities. It is the profile of vaginal microecosystem changes in trichomoniasis that determines the vector of transformation of the vaginal microbiome to...
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| Format: | Article |
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Remedium Group LLC
2022-04-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/6804 |
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| author | V. F. Bezhena O. L. Molchanov N. B. Lazareva L. A. Galiullina A. L. Poznyak |
| author_facet | V. F. Bezhena O. L. Molchanov N. B. Lazareva L. A. Galiullina A. L. Poznyak |
| author_sort | V. F. Bezhena |
| collection | DOAJ |
| description | Introduction. Trichomoniasis is a vaginal infectious and inflammatory disease, which falls into the category of sexually transmissible nosological entities. It is the profile of vaginal microecosystem changes in trichomoniasis that determines the vector of transformation of the vaginal microbiome towards the formation of bacterial vaginosis (BV), namely, a hypercolonized community of anaerobic microorganisms with underlying suppression of the dominant presence of the resident acidophilic microflora.Aim. To evaluate the clinical and bacteriological efficacy of 5-nitroimidazole drugs secnidazole and metronidazole in the therapy of acute trichomoniasis and concomitant vaginal dysbacteriosis.Materials and methods. As a comparison object, we used the therapy regimens for acute trichomoniasis with the 5-nitroimidazole drugs secnidazole and metronidazole, involving 2 grams (g) once as a single dose. The study included 64 patients diagnosed with acute trichomoniasis. The average age of the patients was 34 ± 7 years (95% CI 32–37). The patients were divided into two groups: group 1 (n = 32) used Secnidazole, group 2 (n = 32) used Secnidazole 2 g once as a single dose. Metronidazole was used at a dose of 500 mg 2 times a day for 5 days. Patients were observed by a doctor during two visits, and a follow-up assessment of the treatment results was carried out by way of remote interrogation.Results. The use of the drug therapy ensured removal of Trichomonas from the vagina. Both groups showed relief of clinical symptoms from B1 to B2: discomfort, itching, burning, dyspareunia, hyperemia of the mucosa with underlying tendency towards normalization of laboratory findings of the vaginal microbiocenosis condition. At the same time, it should be noted that the therapy efficiency was higher in group 1 (secnidazole).Conclusion. Thus, the administration of secnidazole provided greater therapeutic efficacy as compared with the use of the similar therapeutic dose and frequency of metronidazole to treat Trichomonas and, in combination with rehabilitation therapy, determined a more pronounced tendency towards normalization of the composition of the vaginal microflora. |
| first_indexed | 2024-04-09T16:39:27Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:39:27Z |
| publishDate | 2022-04-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-c6bf07cad12d4a48a20b2cc437a1b9e32023-04-23T06:56:45ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-04-010514415110.21518/2079-701X-2022-16-5-144-1516112Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosisV. F. Bezhena0O. L. Molchanov1N. B. Lazareva2L. A. Galiullina3A. L. Poznyak4Pavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical University; North-Western State Medical University named after I.I. MechnikovSechenov First Moscow State Medical University (Sechenov University); International Association of Clinical Pharmacology and PharmacyPavlov First Saint Petersburg State Medical UniversityNorth-Western State Medical University named after I.I. MechnikovIntroduction. Trichomoniasis is a vaginal infectious and inflammatory disease, which falls into the category of sexually transmissible nosological entities. It is the profile of vaginal microecosystem changes in trichomoniasis that determines the vector of transformation of the vaginal microbiome towards the formation of bacterial vaginosis (BV), namely, a hypercolonized community of anaerobic microorganisms with underlying suppression of the dominant presence of the resident acidophilic microflora.Aim. To evaluate the clinical and bacteriological efficacy of 5-nitroimidazole drugs secnidazole and metronidazole in the therapy of acute trichomoniasis and concomitant vaginal dysbacteriosis.Materials and methods. As a comparison object, we used the therapy regimens for acute trichomoniasis with the 5-nitroimidazole drugs secnidazole and metronidazole, involving 2 grams (g) once as a single dose. The study included 64 patients diagnosed with acute trichomoniasis. The average age of the patients was 34 ± 7 years (95% CI 32–37). The patients were divided into two groups: group 1 (n = 32) used Secnidazole, group 2 (n = 32) used Secnidazole 2 g once as a single dose. Metronidazole was used at a dose of 500 mg 2 times a day for 5 days. Patients were observed by a doctor during two visits, and a follow-up assessment of the treatment results was carried out by way of remote interrogation.Results. The use of the drug therapy ensured removal of Trichomonas from the vagina. Both groups showed relief of clinical symptoms from B1 to B2: discomfort, itching, burning, dyspareunia, hyperemia of the mucosa with underlying tendency towards normalization of laboratory findings of the vaginal microbiocenosis condition. At the same time, it should be noted that the therapy efficiency was higher in group 1 (secnidazole).Conclusion. Thus, the administration of secnidazole provided greater therapeutic efficacy as compared with the use of the similar therapeutic dose and frequency of metronidazole to treat Trichomonas and, in combination with rehabilitation therapy, determined a more pronounced tendency towards normalization of the composition of the vaginal microflora.https://www.med-sovet.pro/jour/article/view/6804trichomoniasisvaginal dysbacteriosissecnidazolemetronidazoleefficacy |
| spellingShingle | V. F. Bezhena O. L. Molchanov N. B. Lazareva L. A. Galiullina A. L. Poznyak Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis Медицинский совет trichomoniasis vaginal dysbacteriosis secnidazole metronidazole efficacy |
| title | Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis |
| title_full | Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis |
| title_fullStr | Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis |
| title_full_unstemmed | Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis |
| title_short | Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis |
| title_sort | efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis |
| topic | trichomoniasis vaginal dysbacteriosis secnidazole metronidazole efficacy |
| url | https://www.med-sovet.pro/jour/article/view/6804 |
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