Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of &#946;-pancreatic cells. <i>...

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Main Authors: Adriana Jheny Rodríguez-Méndez, Wendy Carmen-Sandoval, Consuelo Lomas-Soria, Ramón G. Guevara-González, Rosalía Reynoso-Camacho, María Elena Villagran-Herrera, Luis Salazar-Olivo, Irineo Torres-Pacheco, Ana A. Feregrino-Pérez
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/23/11/2812
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author Adriana Jheny Rodríguez-Méndez
Wendy Carmen-Sandoval
Consuelo Lomas-Soria
Ramón G. Guevara-González
Rosalía Reynoso-Camacho
María Elena Villagran-Herrera
Luis Salazar-Olivo
Irineo Torres-Pacheco
Ana A. Feregrino-Pérez
author_facet Adriana Jheny Rodríguez-Méndez
Wendy Carmen-Sandoval
Consuelo Lomas-Soria
Ramón G. Guevara-González
Rosalía Reynoso-Camacho
María Elena Villagran-Herrera
Luis Salazar-Olivo
Irineo Torres-Pacheco
Ana A. Feregrino-Pérez
author_sort Adriana Jheny Rodríguez-Méndez
collection DOAJ
description In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of &#946;-pancreatic cells. <i>Acaciella angustissima</i> is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of <i>A. angustissima</i> methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of <i>A. angustissima</i> displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of <i>Acacciella angustissima</i> has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.
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spelling doaj.art-c6c0e2ca904e483093c01e6dc09d17ae2022-12-21T21:52:18ZengMDPI AGMolecules1420-30492018-10-012311281210.3390/molecules23112812molecules23112812Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic RatsAdriana Jheny Rodríguez-Méndez0Wendy Carmen-Sandoval1Consuelo Lomas-Soria2Ramón G. Guevara-González3Rosalía Reynoso-Camacho4María Elena Villagran-Herrera5Luis Salazar-Olivo6Irineo Torres-Pacheco7Ana A. Feregrino-Pérez8Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, MexicoFacultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, MexicoDivisión de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, MexicoDivisión de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, MexicoDepartamento de Investigación y Posgrado en Alimentos, PROPAC, Facultad de Química, Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, MexicoFacultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, MexicoInstituto Potosino de Investigación Científica y Tecnológica, IPICYT, camino a la presa san José 2055, col. Lomas 4 sección, 78216, San Luis Potosí, MexicoDivisión de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, MexicoDivisión de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, MexicoIn Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of &#946;-pancreatic cells. <i>Acaciella angustissima</i> is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of <i>A. angustissima</i> methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of <i>A. angustissima</i> displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of <i>Acacciella angustissima</i> has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.https://www.mdpi.com/1420-3049/23/11/2812<i>Acacciella angustissima</i>streptozotocin-diabetic ratsantidiabetic effectpolyphenolicprotocatechuic acid
spellingShingle Adriana Jheny Rodríguez-Méndez
Wendy Carmen-Sandoval
Consuelo Lomas-Soria
Ramón G. Guevara-González
Rosalía Reynoso-Camacho
María Elena Villagran-Herrera
Luis Salazar-Olivo
Irineo Torres-Pacheco
Ana A. Feregrino-Pérez
Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
Molecules
<i>Acacciella angustissima</i>
streptozotocin-diabetic rats
antidiabetic effect
polyphenolic
protocatechuic acid
title Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
title_full Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
title_fullStr Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
title_full_unstemmed Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
title_short Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
title_sort timbe i acaciella angustissima i pods extracts reduce the levels of glucose insulin and improved physiological parameters hypolipidemic effect oxidative stress and renal damage in streptozotocin induced diabetic rats
topic <i>Acacciella angustissima</i>
streptozotocin-diabetic rats
antidiabetic effect
polyphenolic
protocatechuic acid
url https://www.mdpi.com/1420-3049/23/11/2812
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