Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients
To date, the only available treatment for celiac disease (CD) patients is a life-lasting gluten-free diet (GFD). Lack of adherence to the GFD leads to a significant risk of adverse health consequences. Food cross-contamination, nutritional imbalances, and persistent gastrointestinal symptoms are the...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2674 |
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| author | Giovanni Marasco Giovanna Grazia Cirota Benedetta Rossini Lisa Lungaro Anna Rita Di Biase Antonio Colecchia Umberto Volta Roberto De Giorgio Davide Festi Giacomo Caio |
| author_facet | Giovanni Marasco Giovanna Grazia Cirota Benedetta Rossini Lisa Lungaro Anna Rita Di Biase Antonio Colecchia Umberto Volta Roberto De Giorgio Davide Festi Giacomo Caio |
| author_sort | Giovanni Marasco |
| collection | DOAJ |
| description | To date, the only available treatment for celiac disease (CD) patients is a life-lasting gluten-free diet (GFD). Lack of adherence to the GFD leads to a significant risk of adverse health consequences. Food cross-contamination, nutritional imbalances, and persistent gastrointestinal symptoms are the main concerns related to GFD. Moreover, despite rigid compliance to GFD, patients struggle in achieving a full restoring of the gut microbiota, which plays a role in the nutritive compounds processing, and absorption. Pivotal studies on the supplementation of GFD with probiotics, such as <i>Bifidobacterium</i> and <i>Lactobacilli</i>, reported a potential to restore gut microbiota composition and to pre-digest gluten in the intestinal lumen, reducing the inflammation associated with gluten intake, the intestinal permeability, and the cytokine and antibody production. These findings could explain an improvement in symptoms and quality of life in patients treated with GFD and probiotics. On the other hand, the inclusion of prebiotics in GFD could also be easy to administer and cost-effective as an adjunctive treatment for CD, having the power to stimulate the growth of potentially health-promoting bacteria strains. However, evidence regarding the use of prebiotics and probiotics in patients with CD is still insufficient to justify their use in clinical practice. |
| first_indexed | 2024-03-10T16:38:11Z |
| format | Article |
| id | doaj.art-c6c7f18df0144023a9430a2abb03b002 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:38:11Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c6c7f18df0144023a9430a2abb03b0022023-11-20T12:17:14ZengMDPI AGNutrients2072-66432020-09-01129267410.3390/nu12092674Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease PatientsGiovanni Marasco0Giovanna Grazia Cirota1Benedetta Rossini2Lisa Lungaro3Anna Rita Di Biase4Antonio Colecchia5Umberto Volta6Roberto De Giorgio7Davide Festi8Giacomo Caio9Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44124 Ferrara, ItalyDepartment of Pediatrics, Policlinic Hospital, University of Modena, Via del Pozzo 71, 41126 Modena, ItalyGastroenterology Unit, Borgo Trento University Hospital of Verona, P.le Aristide Stefani 1, 37126 Verona, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44124 Ferrara, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44124 Ferrara, ItalyTo date, the only available treatment for celiac disease (CD) patients is a life-lasting gluten-free diet (GFD). Lack of adherence to the GFD leads to a significant risk of adverse health consequences. Food cross-contamination, nutritional imbalances, and persistent gastrointestinal symptoms are the main concerns related to GFD. Moreover, despite rigid compliance to GFD, patients struggle in achieving a full restoring of the gut microbiota, which plays a role in the nutritive compounds processing, and absorption. Pivotal studies on the supplementation of GFD with probiotics, such as <i>Bifidobacterium</i> and <i>Lactobacilli</i>, reported a potential to restore gut microbiota composition and to pre-digest gluten in the intestinal lumen, reducing the inflammation associated with gluten intake, the intestinal permeability, and the cytokine and antibody production. These findings could explain an improvement in symptoms and quality of life in patients treated with GFD and probiotics. On the other hand, the inclusion of prebiotics in GFD could also be easy to administer and cost-effective as an adjunctive treatment for CD, having the power to stimulate the growth of potentially health-promoting bacteria strains. However, evidence regarding the use of prebiotics and probiotics in patients with CD is still insufficient to justify their use in clinical practice.https://www.mdpi.com/2072-6643/12/9/2674celiac diseaseCDgut microbiotaprobioticsprebioticsoat |
| spellingShingle | Giovanni Marasco Giovanna Grazia Cirota Benedetta Rossini Lisa Lungaro Anna Rita Di Biase Antonio Colecchia Umberto Volta Roberto De Giorgio Davide Festi Giacomo Caio Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients Nutrients celiac disease CD gut microbiota probiotics prebiotics oat |
| title | Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients |
| title_full | Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients |
| title_fullStr | Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients |
| title_full_unstemmed | Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients |
| title_short | Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients |
| title_sort | probiotics prebiotics and other dietary supplements for gut microbiota modulation in celiac disease patients |
| topic | celiac disease CD gut microbiota probiotics prebiotics oat |
| url | https://www.mdpi.com/2072-6643/12/9/2674 |
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