Multigenerational epigenetic effects of nicotine on lung function
<p>Abstract</p> <p>A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of <it>in utero </it>nicotine exposure, Rehan <it>et al</...
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| Format: | Article |
| Language: | English |
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BMC
2013-02-01
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| Series: | BMC Medicine |
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| Online Access: | http://www.biomedcentral.com/1741-7015/11/27 |
| _version_ | 1818919619571744768 |
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| author | Leslie Frances M |
| author_facet | Leslie Frances M |
| author_sort | Leslie Frances M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of <it>in utero </it>nicotine exposure, Rehan <it>et al</it>. have now demonstrated multigenerational effects of nicotine that could explain this 'grandmother effect'. F1 offspring of nicotine-treated pregnant rats exhibited asthma-like changes to lung function and associated epigenetic changes to DNA and histones in both lungs and gonads. These alterations were blocked by co-administration of the peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, implicating downregulation of this receptor in the nicotine effects. F2 offspring of F1 mated animals exhibited similar changes in lung function to that of their parents, even though they had never been exposed to nicotine. Thus epigenetic mechanisms appear to underlie the multigenerational transmission of a nicotine-induced asthma-like phenotype. These findings emphasize the need for more effective smoking cessation strategies during pregnancy, and cast further doubt on the safety of using nicotine replacement therapy to reduce tobacco use in pregnant women.</p> <p>Please see related article: <url>http://www.biomedcentral.com/1741-7015/10/129</url></p> |
| first_indexed | 2024-12-20T01:08:44Z |
| format | Article |
| id | doaj.art-c6d1d22da3644ca49fbb1bf7b627cb2e |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-20T01:08:44Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-c6d1d22da3644ca49fbb1bf7b627cb2e2022-12-21T19:58:46ZengBMCBMC Medicine1741-70152013-02-011112710.1186/1741-7015-11-27Multigenerational epigenetic effects of nicotine on lung functionLeslie Frances M<p>Abstract</p> <p>A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of <it>in utero </it>nicotine exposure, Rehan <it>et al</it>. have now demonstrated multigenerational effects of nicotine that could explain this 'grandmother effect'. F1 offspring of nicotine-treated pregnant rats exhibited asthma-like changes to lung function and associated epigenetic changes to DNA and histones in both lungs and gonads. These alterations were blocked by co-administration of the peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, implicating downregulation of this receptor in the nicotine effects. F2 offspring of F1 mated animals exhibited similar changes in lung function to that of their parents, even though they had never been exposed to nicotine. Thus epigenetic mechanisms appear to underlie the multigenerational transmission of a nicotine-induced asthma-like phenotype. These findings emphasize the need for more effective smoking cessation strategies during pregnancy, and cast further doubt on the safety of using nicotine replacement therapy to reduce tobacco use in pregnant women.</p> <p>Please see related article: <url>http://www.biomedcentral.com/1741-7015/10/129</url></p>http://www.biomedcentral.com/1741-7015/11/27developmentDNA methylationhistone acetylationnicotine replacement therapy (NRT)peroxisome proliferator-activated receptor-γ (PPARγ)smokingtobacco |
| spellingShingle | Leslie Frances M Multigenerational epigenetic effects of nicotine on lung function BMC Medicine development DNA methylation histone acetylation nicotine replacement therapy (NRT) peroxisome proliferator-activated receptor-γ (PPARγ) smoking tobacco |
| title | Multigenerational epigenetic effects of nicotine on lung function |
| title_full | Multigenerational epigenetic effects of nicotine on lung function |
| title_fullStr | Multigenerational epigenetic effects of nicotine on lung function |
| title_full_unstemmed | Multigenerational epigenetic effects of nicotine on lung function |
| title_short | Multigenerational epigenetic effects of nicotine on lung function |
| title_sort | multigenerational epigenetic effects of nicotine on lung function |
| topic | development DNA methylation histone acetylation nicotine replacement therapy (NRT) peroxisome proliferator-activated receptor-γ (PPARγ) smoking tobacco |
| url | http://www.biomedcentral.com/1741-7015/11/27 |
| work_keys_str_mv | AT lesliefrancesm multigenerationalepigeneticeffectsofnicotineonlungfunction |