Exploring the effect of different linkers on self-assembly, ROS-sensitivity and anticancer efficacy of hydroxyethyl starch-curcumin prodrug

Exploring the effect of different linkers on self-assembly, ROS-sensitivity and anticancer efficacy of hydroxyethyl starch-curcumin prodrug

Curcumin is a BCPR inhibitor, antiproliferative agent and apoptotic inducer to cancer cells, which is poorly soluble in water. In order to broaden the application of curcumin, conjugations of quaternary ammonium substituted hydroxyethyl starch (QHES) with curcumin by thioether bond (QHES-2S-CUR), di...

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Bibliographic Details
Main Authors:	Zi-Dan Wang, Hu-Hong Peng, Dong-Qiang Lin, Yi-Xin Guan
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Series:	Carbohydrate Polymer Technologies and Applications
Subjects:	Hydroxyethyl starch Curcumin Prodrug Linker ROS-responsive Self-assembly
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666893923000452

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