Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study
Abstract Background Osteonecrosis of the femoral head is a degenerative condition linked to corticosteroids, alcoholism, or trauma. With its rising prevalence due to increased hormone drug use and its debilitating effects on young to middle-aged individuals, understanding its association with specif...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-04235-0 |
| _version_ | 1797557745342218240 |
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| author | Haotian Zheng Binglin Ye Kesong Huang Xiangming Gao Wei Chen |
| author_facet | Haotian Zheng Binglin Ye Kesong Huang Xiangming Gao Wei Chen |
| author_sort | Haotian Zheng |
| collection | DOAJ |
| description | Abstract Background Osteonecrosis of the femoral head is a degenerative condition linked to corticosteroids, alcoholism, or trauma. With its rising prevalence due to increased hormone drug use and its debilitating effects on young to middle-aged individuals, understanding its association with specific laboratory indicators can aid early diagnosis and prevention. Methods Upon retrospective analysis of the clinical data pertaining to individuals diagnosed with femoral head necrosis, spanning from January 2016 to January 2022, a comprehensive evaluation was conducted within the same time frame. The study aimed to ascertain the presence of femoral head necrosis in a total of 1176 individuals. A total of 1036 healthy patients were recruited randomly, ensuring that their ages matched. The risk variables associated with the utilization of logistic regression analysis and analysis techniques are employed. The patient examines the age distribution within a specific age group. Results The levels of high-density lipoprotein, low-density lipoprotein A1, lipoprotein B1, total protein, albumin, globulin, and other lipophilic metabolism and coagulation markers exhibited a statistically significant increase compared to the control group. A multifactor logistic regression analysis was conducted to identify potential risk factors associated with femoral head necrosis in patients. Conclusion Femoral head necrosis is associated with a range of variables including coagulation malfunction, lipid metabolic abnormalities, and inflammation. |
| first_indexed | 2024-03-10T17:20:46Z |
| format | Article |
| id | doaj.art-c6d616cd0d5243ad8284778327bf2c4b |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-10T17:20:46Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-c6d616cd0d5243ad8284778327bf2c4b2023-11-20T10:20:42ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-10-0118111310.1186/s13018-023-04235-0Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative studyHaotian Zheng0Binglin Ye1Kesong Huang2Xiangming Gao3Wei Chen4Second Affiliated Hospital of Heilongjiang University of Chinese MedicineDepartment of Orthopaedics, Traditional Chinese Medical Hospital of Gansu ProvinceGansu University of Chinese MedicinePuyang Medical CollegeDepartment of Orthopaedics, Traditional Chinese Medical Hospital of Gansu ProvinceAbstract Background Osteonecrosis of the femoral head is a degenerative condition linked to corticosteroids, alcoholism, or trauma. With its rising prevalence due to increased hormone drug use and its debilitating effects on young to middle-aged individuals, understanding its association with specific laboratory indicators can aid early diagnosis and prevention. Methods Upon retrospective analysis of the clinical data pertaining to individuals diagnosed with femoral head necrosis, spanning from January 2016 to January 2022, a comprehensive evaluation was conducted within the same time frame. The study aimed to ascertain the presence of femoral head necrosis in a total of 1176 individuals. A total of 1036 healthy patients were recruited randomly, ensuring that their ages matched. The risk variables associated with the utilization of logistic regression analysis and analysis techniques are employed. The patient examines the age distribution within a specific age group. Results The levels of high-density lipoprotein, low-density lipoprotein A1, lipoprotein B1, total protein, albumin, globulin, and other lipophilic metabolism and coagulation markers exhibited a statistically significant increase compared to the control group. A multifactor logistic regression analysis was conducted to identify potential risk factors associated with femoral head necrosis in patients. Conclusion Femoral head necrosis is associated with a range of variables including coagulation malfunction, lipid metabolic abnormalities, and inflammation.https://doi.org/10.1186/s13018-023-04235-0Femoral head necrosisRoutine bloodBiochemical IndicatorsRetrospective casesRisk factors |
| spellingShingle | Haotian Zheng Binglin Ye Kesong Huang Xiangming Gao Wei Chen Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study Journal of Orthopaedic Surgery and Research Femoral head necrosis Routine blood Biochemical Indicators Retrospective cases Risk factors |
| title | Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study |
| title_full | Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study |
| title_fullStr | Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study |
| title_full_unstemmed | Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study |
| title_short | Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study |
| title_sort | laboratory indices in patients with osteonecrosis of the femoral head a retrospective comparative study |
| topic | Femoral head necrosis Routine blood Biochemical Indicators Retrospective cases Risk factors |
| url | https://doi.org/10.1186/s13018-023-04235-0 |
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