Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting bra...

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Bibliographic Details
Main Authors: Lijing Xin, Özlem Ipek, Maurice Beaumont, Maya Shevlyakova, Nicolas Christinat, Mojgan Masoodi, Norman Greenberg, Rolf Gruetter, Bernard Cuenoud
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Nutrition
Subjects:
ketones
NAD
brain energy metabolism
medium chain triglycerides
hydroxybutyrates
phosphorus magnetic resonance spectorscopy
Online Access:https://www.frontiersin.org/article/10.3389/fnut.2018.00062/full
Description
Summary:Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.
ISSN:2296-861X

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