Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting bra...

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Bibliographic Details
Main Authors: Lijing Xin, Özlem Ipek, Maurice Beaumont, Maya Shevlyakova, Nicolas Christinat, Mojgan Masoodi, Norman Greenberg, Rolf Gruetter, Bernard Cuenoud
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Nutrition
Subjects:
ketones
NAD
brain energy metabolism
medium chain triglycerides
hydroxybutyrates
phosphorus magnetic resonance spectorscopy
Online Access:https://www.frontiersin.org/article/10.3389/fnut.2018.00062/full

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