The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins
In fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm1, Mdm12, Mdm34, and Mdm10) assemble to form the ERMES compl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-12-01
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| Series: | Contact |
| Online Access: | https://doi.org/10.1177/25152564211064491 |
| _version_ | 1818537451044470784 |
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| author | Javairia Y. Cheema Jiajia He Wenfan Wei Chuanhai Fu |
| author_facet | Javairia Y. Cheema Jiajia He Wenfan Wei Chuanhai Fu |
| author_sort | Javairia Y. Cheema |
| collection | DOAJ |
| description | In fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm1, Mdm12, Mdm34, and Mdm10) assemble to form the ERMES complex while regulator proteins are required for regulating the organization and function of the ERMES complex. Multiple regulator proteins, including Gem1, Lam6, Tom7, and Emr1, of the ERMES complex, have been identified recently. In this review, we discuss the organization of the ERMES complex and the roles of the regulator proteins of the ERMES complex. |
| first_indexed | 2024-12-11T18:50:54Z |
| format | Article |
| id | doaj.art-c6d74cea2bde4d6d8ba75afd766c5dec |
| institution | Directory Open Access Journal |
| issn | 2515-2564 |
| language | English |
| last_indexed | 2024-12-11T18:50:54Z |
| publishDate | 2021-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Contact |
| spelling | doaj.art-c6d74cea2bde4d6d8ba75afd766c5dec2022-12-22T00:54:19ZengSAGE PublishingContact2515-25642021-12-01410.1177/25152564211064491The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory ProteinsJavairia Y. CheemaJiajia HeWenfan WeiChuanhai FuIn fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm1, Mdm12, Mdm34, and Mdm10) assemble to form the ERMES complex while regulator proteins are required for regulating the organization and function of the ERMES complex. Multiple regulator proteins, including Gem1, Lam6, Tom7, and Emr1, of the ERMES complex, have been identified recently. In this review, we discuss the organization of the ERMES complex and the roles of the regulator proteins of the ERMES complex.https://doi.org/10.1177/25152564211064491 |
| spellingShingle | Javairia Y. Cheema Jiajia He Wenfan Wei Chuanhai Fu The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins Contact |
| title | The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins |
| title_full | The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins |
| title_fullStr | The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins |
| title_full_unstemmed | The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins |
| title_short | The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins |
| title_sort | endoplasmic reticulum mitochondria encounter structure and its regulatory proteins |
| url | https://doi.org/10.1177/25152564211064491 |
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