Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study
Hypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can initiate the progression of various diseases...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345717/full |
| _version_ | 1827312415227772928 |
|---|---|
| author | Kaikai Xue Kaikai Xue Guojian Zhang Guojian Zhang Zihao Li Zihao Li Xiangtao Zeng Xiangtao Zeng Zi Li Fulin Wang Xingxing Zhang Cai Lin Cong Mao |
| author_facet | Kaikai Xue Kaikai Xue Guojian Zhang Guojian Zhang Zihao Li Zihao Li Xiangtao Zeng Xiangtao Zeng Zi Li Fulin Wang Xingxing Zhang Cai Lin Cong Mao |
| author_sort | Kaikai Xue |
| collection | DOAJ |
| description | Hypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can initiate the progression of various diseases through the intricate interplay between gut microbiota and the host. However, the precise nature of the causal link between gut microbiota and hypertrophic scarring remains uncertain. In this study, after compiling summary data from genome-wide association studies (GWAS) involving 418 instances of gut microbiota and hypertrophic scarring, we conducted a bidirectional Mendelian randomization (MR) to investigate the potential existence of a causal relationship between gut microbiota and the development of hypertrophic scar and to discern the directionality of causation. By utilizing MR analysis, we identified seven causal associations between gut microbiome and hypertrophic scarring, involving one positive and six negative causal directions. Among them, Intestinimonas, Ruminococcus2, Barnesiella, Dorea, Desulfovibrio piger, and Ruminococcus torques act as protective factors against hypertrophic scarring, while Eubacterium rectale suggests a potential role as a risk factor for hypertrophic scars. Additionally, sensitivity analyses of these results revealed no indications of heterogeneity or pleiotropy. The findings of our MR study suggest a potential causative link between gut microbiota and hypertrophic scarring, opening up new ways for future mechanistic research and the exploration of nanobiotechnology therapies for skin disorders. |
| first_indexed | 2024-04-24T21:44:04Z |
| format | Article |
| id | doaj.art-c6dc28a9fca9446d88d7f290e699894b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T21:44:04Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-c6dc28a9fca9446d88d7f290e699894b2024-03-21T05:11:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-03-011510.3389/fmicb.2024.13457171345717Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization studyKaikai Xue0Kaikai Xue1Guojian Zhang2Guojian Zhang3Zihao Li4Zihao Li5Xiangtao Zeng6Xiangtao Zeng7Zi Li8Fulin Wang9Xingxing Zhang10Cai Lin11Cong Mao12Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Burn, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Burn, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Burn, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Burn, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Burn, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaHypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can initiate the progression of various diseases through the intricate interplay between gut microbiota and the host. However, the precise nature of the causal link between gut microbiota and hypertrophic scarring remains uncertain. In this study, after compiling summary data from genome-wide association studies (GWAS) involving 418 instances of gut microbiota and hypertrophic scarring, we conducted a bidirectional Mendelian randomization (MR) to investigate the potential existence of a causal relationship between gut microbiota and the development of hypertrophic scar and to discern the directionality of causation. By utilizing MR analysis, we identified seven causal associations between gut microbiome and hypertrophic scarring, involving one positive and six negative causal directions. Among them, Intestinimonas, Ruminococcus2, Barnesiella, Dorea, Desulfovibrio piger, and Ruminococcus torques act as protective factors against hypertrophic scarring, while Eubacterium rectale suggests a potential role as a risk factor for hypertrophic scars. Additionally, sensitivity analyses of these results revealed no indications of heterogeneity or pleiotropy. The findings of our MR study suggest a potential causative link between gut microbiota and hypertrophic scarring, opening up new ways for future mechanistic research and the exploration of nanobiotechnology therapies for skin disorders.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345717/fullgut microbiotahypertrophic scarFirmicutesMendelian randomizationGWAS |
| spellingShingle | Kaikai Xue Kaikai Xue Guojian Zhang Guojian Zhang Zihao Li Zihao Li Xiangtao Zeng Xiangtao Zeng Zi Li Fulin Wang Xingxing Zhang Cai Lin Cong Mao Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study Frontiers in Microbiology gut microbiota hypertrophic scar Firmicutes Mendelian randomization GWAS |
| title | Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study |
| title_full | Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study |
| title_fullStr | Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study |
| title_full_unstemmed | Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study |
| title_short | Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study |
| title_sort | dissecting the association between gut microbiota and hypertrophic scarring a bidirectional mendelian randomization study |
| topic | gut microbiota hypertrophic scar Firmicutes Mendelian randomization GWAS |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345717/full |
| work_keys_str_mv | AT kaikaixue dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT kaikaixue dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT guojianzhang dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT guojianzhang dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT zihaoli dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT zihaoli dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT xiangtaozeng dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT xiangtaozeng dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT zili dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT fulinwang dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT xingxingzhang dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT cailin dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy AT congmao dissectingtheassociationbetweengutmicrobiotaandhypertrophicscarringabidirectionalmendelianrandomizationstudy |