Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy
Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/1/179 |
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| author | Miguel A. Ortega Oscar Fraile-Martinez Cielo García-Montero Sonia Rodriguez-Martín Rosa M. Funes Moñux Coral Bravo Juan A. De Leon-Luis Jose V. Saz Miguel A. Saez Luis G. Guijarro Guillermo Lahera Jorge Monserrat Fernando Mora Javier Quintero Julia Bujan Natalio García-Honduvilla Melchor Alvarez-Mon Miguel Angel Alvarez-Mon |
| author_facet | Miguel A. Ortega Oscar Fraile-Martinez Cielo García-Montero Sonia Rodriguez-Martín Rosa M. Funes Moñux Coral Bravo Juan A. De Leon-Luis Jose V. Saz Miguel A. Saez Luis G. Guijarro Guillermo Lahera Jorge Monserrat Fernando Mora Javier Quintero Julia Bujan Natalio García-Honduvilla Melchor Alvarez-Mon Miguel Angel Alvarez-Mon |
| author_sort | Miguel A. Ortega |
| collection | DOAJ |
| description | Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for the first time during pregnancy, which is detrimental to maternofetal well-being. The impact of having a first episode of psychosis during pregnancy on the placenta has not yet been explored. Oxidative stress is thought to take part in the etiopathogenesis of this complex disorder, and this condition can also affect the placenta as it is highly sensitive to changes in the maternal environment. In this sense, the aim of the present work was to study the gene and protein expression through RT–qPCR and immunohistochemistry, respectively, of oxidative stress markers (NOX-1, NOX-2, iNOS, eNOS and PARP) in the placental tissue of women who underwent a first episode of psychosis during pregnancy (FE-PW) in comparison to healthy pregnant women. Our results showed augmented gene and protein expression of NOX-1, NOX-2, iNOS and PARP in the placental tissue of FE-PW. For the first time, we demonstrated that oxidative stress may have an important pathophysiological role in this tissue, aiding in explaining the impact of psychosis on pregnancy and the need for future studies in this field to guide better clinical management of these patients. |
| first_indexed | 2024-03-09T13:46:33Z |
| format | Article |
| id | doaj.art-c6ddfdb4e5914be78c419279dfd4fd84 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:46:33Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c6ddfdb4e5914be78c419279dfd4fd842023-11-30T20:59:27ZengMDPI AGAntioxidants2076-39212023-01-0112117910.3390/antiox12010179Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during PregnancyMiguel A. Ortega0Oscar Fraile-Martinez1Cielo García-Montero2Sonia Rodriguez-Martín3Rosa M. Funes Moñux4Coral Bravo5Juan A. De Leon-Luis6Jose V. Saz7Miguel A. Saez8Luis G. Guijarro9Guillermo Lahera10Jorge Monserrat11Fernando Mora12Javier Quintero13Julia Bujan14Natalio García-Honduvilla15Melchor Alvarez-Mon16Miguel Angel Alvarez-Mon17Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Biomedicine and Biotechnology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainPsychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for the first time during pregnancy, which is detrimental to maternofetal well-being. The impact of having a first episode of psychosis during pregnancy on the placenta has not yet been explored. Oxidative stress is thought to take part in the etiopathogenesis of this complex disorder, and this condition can also affect the placenta as it is highly sensitive to changes in the maternal environment. In this sense, the aim of the present work was to study the gene and protein expression through RT–qPCR and immunohistochemistry, respectively, of oxidative stress markers (NOX-1, NOX-2, iNOS, eNOS and PARP) in the placental tissue of women who underwent a first episode of psychosis during pregnancy (FE-PW) in comparison to healthy pregnant women. Our results showed augmented gene and protein expression of NOX-1, NOX-2, iNOS and PARP in the placental tissue of FE-PW. For the first time, we demonstrated that oxidative stress may have an important pathophysiological role in this tissue, aiding in explaining the impact of psychosis on pregnancy and the need for future studies in this field to guide better clinical management of these patients.https://www.mdpi.com/2076-3921/12/1/179psychosis during pregnancyoxidative stressplacentamaternofetal well-beingNADPH oxidases (NOX)nitric oxide synthases (NOS) |
| spellingShingle | Miguel A. Ortega Oscar Fraile-Martinez Cielo García-Montero Sonia Rodriguez-Martín Rosa M. Funes Moñux Coral Bravo Juan A. De Leon-Luis Jose V. Saz Miguel A. Saez Luis G. Guijarro Guillermo Lahera Jorge Monserrat Fernando Mora Javier Quintero Julia Bujan Natalio García-Honduvilla Melchor Alvarez-Mon Miguel Angel Alvarez-Mon Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy Antioxidants psychosis during pregnancy oxidative stress placenta maternofetal well-being NADPH oxidases (NOX) nitric oxide synthases (NOS) |
| title | Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy |
| title_full | Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy |
| title_fullStr | Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy |
| title_full_unstemmed | Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy |
| title_short | Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy |
| title_sort | evidence of increased oxidative stress in the placental tissue of women who suffered an episode of psychosis during pregnancy |
| topic | psychosis during pregnancy oxidative stress placenta maternofetal well-being NADPH oxidases (NOX) nitric oxide synthases (NOS) |
| url | https://www.mdpi.com/2076-3921/12/1/179 |
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