Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

Abstract Background Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly sensitive to ferroptosis, a form of regulated cell...

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Bibliographic Details
Main Authors: Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson, Martin C. Sadowski
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer & Metabolism
Subjects:
Therapy resistance
Multidrug tolerance
Metabolic reprograming
Lipid remodeling
Lipid uptake
Ferroptosis
Online Access:http://link.springer.com/article/10.1186/s40170-020-00217-6

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