A short history from Karelia study to biodiversity and public health interventions
Contact with natural environments enriches the human microbiome, promotes immune balance and protects against allergies and inflammatory disorders. In Finland, the allergy & asthma epidemic became slowly visible in mid 1960s. After the World War II, Karelia was split into Finnish and Soviet...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Allergy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2023.1152927/full |
| _version_ | 1797871241084796928 |
|---|---|
| author | Tari Haahtela Tari Haahtela Harri Alenius Harri Alenius Petri Auvinen Nanna Fyhrquist Leena von Hertzen Pekka Jousilahti Piia Karisola Tiina Laatikainen Tiina Laatikainen Jenni Lehtimäki Laura Paalanen Lasse Ruokolainen Kimmo Saarinen Erkka Valovirta Erkka Valovirta Tuula Vasankari Tuula Vasankari Tiina Vlasoff Marina Erhola Jean Bousquet Jean Bousquet Jean Bousquet Erkki Vartiainen Mika J. Mäkelä Mika J. Mäkelä |
| author_facet | Tari Haahtela Tari Haahtela Harri Alenius Harri Alenius Petri Auvinen Nanna Fyhrquist Leena von Hertzen Pekka Jousilahti Piia Karisola Tiina Laatikainen Tiina Laatikainen Jenni Lehtimäki Laura Paalanen Lasse Ruokolainen Kimmo Saarinen Erkka Valovirta Erkka Valovirta Tuula Vasankari Tuula Vasankari Tiina Vlasoff Marina Erhola Jean Bousquet Jean Bousquet Jean Bousquet Erkki Vartiainen Mika J. Mäkelä Mika J. Mäkelä |
| author_sort | Tari Haahtela |
| collection | DOAJ |
| description | Contact with natural environments enriches the human microbiome, promotes immune balance and protects against allergies and inflammatory disorders. In Finland, the allergy & asthma epidemic became slowly visible in mid 1960s. After the World War II, Karelia was split into Finnish and Soviet Union (now Russia) territories. This led to more marked environmental and lifestyle changes in the Finnish compared with Russian Karelia. The Karelia Allergy Study 2002–2022 showed that allergic conditions were much more common on the Finnish side. The Russians had richer gene-microbe network and interaction than the Finns, which associated with better balanced immune regulatory circuits and lower allergy prevalence. In the Finnish adolescents, a biodiverse natural environment around the homes associated with lower occurrence of allergies. Overall, the plausible explanation of the allergy disparity was the prominent change in environment and lifestyle in the Finnish Karelia from 1940s to 1980s. The nationwide Finnish Allergy Programme 2008–2018 implemented the biodiversity hypothesis into practice by endorsing immune tolerance, nature contacts, and allergy health with favorable results. A regional health and environment programme, Nature Step to Health 2022–2032, has been initiated in the City of Lahti, EU Green Capital 2021. The programme integrates prevention of chronic diseases (asthma, diabetes, obesity, depression), nature loss, and climate crisis in the spirit of Planetary Health. Allergic diseases exemplify inappropriate immunological responses to natural environment. Successful management of the epidemics of allergy and other non-communicable diseases may pave the way to improve human and environmental health. |
| first_indexed | 2024-04-10T00:41:02Z |
| format | Article |
| id | doaj.art-c6e375d6f15d40ed8bff002ccf57bfb4 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-04-10T00:41:02Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-c6e375d6f15d40ed8bff002ccf57bfb42023-03-14T06:11:06ZengFrontiers Media S.A.Frontiers in Allergy2673-61012023-03-01410.3389/falgy.2023.11529271152927A short history from Karelia study to biodiversity and public health interventionsTari Haahtela0Tari Haahtela1Harri Alenius2Harri Alenius3Petri Auvinen4Nanna Fyhrquist5Leena von Hertzen6Pekka Jousilahti7Piia Karisola8Tiina Laatikainen9Tiina Laatikainen10Jenni Lehtimäki11Laura Paalanen12Lasse Ruokolainen13Kimmo Saarinen14Erkka Valovirta15Erkka Valovirta16Tuula Vasankari17Tuula Vasankari18Tiina Vlasoff19Marina Erhola20Jean Bousquet21Jean Bousquet22Jean Bousquet23Erkki Vartiainen24Mika J. Mäkelä25Mika J. Mäkelä26Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, FinlandUniversity of Helsinki, Helsinki, FinlandHuman Microbiome Research (HUMI), Faculty of Medicine, University of Helsinki, Helsinki, FinlandInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenDNA Sequencing and GenomicsLaboratory, Institute of Biotechnology, Helsinki, FinlandInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenUniversity of Helsinki, Helsinki, FinlandDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, FinlandHuman Microbiome Research (HUMI), Faculty of Medicine, University of Helsinki, Helsinki, FinlandDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, FinlandInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandFinnish Environment Institute, Helsinki, FinlandDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, FinlandDepartment of Biosciences, University of Helsinki, Helsinki, Finland0University of Eastern Finland, Joensuu, Finland1Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland2Allergy Clinic, Terveystalo, Turku, Finland1Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland3Finnish Lung Health Association (FILHA), Helsinki, Finland4North Karelia Centre for Public Health, Joensuu, Finland5Pirkanmaa Joint Authority for Health Services and Social Welfare, Tampere, Finland6Institute of Allergology, Charité — Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany7Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany8University Hospital Montpellier, Montpellier, FranceDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, FinlandSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, FinlandUniversity of Helsinki, Helsinki, FinlandContact with natural environments enriches the human microbiome, promotes immune balance and protects against allergies and inflammatory disorders. In Finland, the allergy & asthma epidemic became slowly visible in mid 1960s. After the World War II, Karelia was split into Finnish and Soviet Union (now Russia) territories. This led to more marked environmental and lifestyle changes in the Finnish compared with Russian Karelia. The Karelia Allergy Study 2002–2022 showed that allergic conditions were much more common on the Finnish side. The Russians had richer gene-microbe network and interaction than the Finns, which associated with better balanced immune regulatory circuits and lower allergy prevalence. In the Finnish adolescents, a biodiverse natural environment around the homes associated with lower occurrence of allergies. Overall, the plausible explanation of the allergy disparity was the prominent change in environment and lifestyle in the Finnish Karelia from 1940s to 1980s. The nationwide Finnish Allergy Programme 2008–2018 implemented the biodiversity hypothesis into practice by endorsing immune tolerance, nature contacts, and allergy health with favorable results. A regional health and environment programme, Nature Step to Health 2022–2032, has been initiated in the City of Lahti, EU Green Capital 2021. The programme integrates prevention of chronic diseases (asthma, diabetes, obesity, depression), nature loss, and climate crisis in the spirit of Planetary Health. Allergic diseases exemplify inappropriate immunological responses to natural environment. Successful management of the epidemics of allergy and other non-communicable diseases may pave the way to improve human and environmental health.https://www.frontiersin.org/articles/10.3389/falgy.2023.1152927/fullallergy epidemicallergy programmeasthmabiodiversity hypothesisclimate changeKarelia Allergy Study |
| spellingShingle | Tari Haahtela Tari Haahtela Harri Alenius Harri Alenius Petri Auvinen Nanna Fyhrquist Leena von Hertzen Pekka Jousilahti Piia Karisola Tiina Laatikainen Tiina Laatikainen Jenni Lehtimäki Laura Paalanen Lasse Ruokolainen Kimmo Saarinen Erkka Valovirta Erkka Valovirta Tuula Vasankari Tuula Vasankari Tiina Vlasoff Marina Erhola Jean Bousquet Jean Bousquet Jean Bousquet Erkki Vartiainen Mika J. Mäkelä Mika J. Mäkelä A short history from Karelia study to biodiversity and public health interventions Frontiers in Allergy allergy epidemic allergy programme asthma biodiversity hypothesis climate change Karelia Allergy Study |
| title | A short history from Karelia study to biodiversity and public health interventions |
| title_full | A short history from Karelia study to biodiversity and public health interventions |
| title_fullStr | A short history from Karelia study to biodiversity and public health interventions |
| title_full_unstemmed | A short history from Karelia study to biodiversity and public health interventions |
| title_short | A short history from Karelia study to biodiversity and public health interventions |
| title_sort | short history from karelia study to biodiversity and public health interventions |
| topic | allergy epidemic allergy programme asthma biodiversity hypothesis climate change Karelia Allergy Study |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2023.1152927/full |
| work_keys_str_mv | AT tarihaahtela ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tarihaahtela ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT harrialenius ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT harrialenius ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT petriauvinen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT nannafyhrquist ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT leenavonhertzen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT pekkajousilahti ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT piiakarisola ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tiinalaatikainen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tiinalaatikainen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jennilehtimaki ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT laurapaalanen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT lasseruokolainen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT kimmosaarinen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT erkkavalovirta ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT erkkavalovirta ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tuulavasankari ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tuulavasankari ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tiinavlasoff ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT marinaerhola ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jeanbousquet ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jeanbousquet ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jeanbousquet ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT erkkivartiainen ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT mikajmakela ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT mikajmakela ashorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tarihaahtela shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tarihaahtela shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT harrialenius shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT harrialenius shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT petriauvinen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT nannafyhrquist shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT leenavonhertzen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT pekkajousilahti shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT piiakarisola shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tiinalaatikainen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tiinalaatikainen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jennilehtimaki shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT laurapaalanen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT lasseruokolainen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT kimmosaarinen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT erkkavalovirta shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT erkkavalovirta shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tuulavasankari shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tuulavasankari shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT tiinavlasoff shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT marinaerhola shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jeanbousquet shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jeanbousquet shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT jeanbousquet shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT erkkivartiainen shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT mikajmakela shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions AT mikajmakela shorthistoryfromkareliastudytobiodiversityandpublichealthinterventions |