Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy
Background: Despite the effectiveness of allergen immunotherapy (AIT), some patients are unresponsive for reasons still unknown; yet validated response biomarkers remain unavailable. Objective: To analyze immunological parameters as biomarkers to monitor and predict clinical response to a MicroCryst...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455121000399 |
| _version_ | 1819098185398747136 |
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| author | José L. Justicia Clara Padró Albert Roger Francisco Moreno Manuel J. Rial Antonio Parra Antonio Valero Alfons Malet Aina Teniente Anna Boronat Carla Torán-Barona |
| author_facet | José L. Justicia Clara Padró Albert Roger Francisco Moreno Manuel J. Rial Antonio Parra Antonio Valero Alfons Malet Aina Teniente Anna Boronat Carla Torán-Barona |
| author_sort | José L. Justicia |
| collection | DOAJ |
| description | Background: Despite the effectiveness of allergen immunotherapy (AIT), some patients are unresponsive for reasons still unknown; yet validated response biomarkers remain unavailable. Objective: To analyze immunological parameters as biomarkers to monitor and predict clinical response to a MicroCrystalline Tyrosine-adjuvanted house dust mite (HDM) AIT in patients with allergic rhinitis (AR). Methods: Observational, prospective, multicenter study including adult patients (aged 18–65 years) with AR, with and without asthma, sensitized to the HDM Dermatophagoides pteronyssinus (DP) and prescribed Acarovac Plus® DP 100% in the routine practice. Serum concentrations of total IgE, specific IgE, specific IgG4, IL-4, IL-5, IL-10, IL-13, and IFN-γ were compared between baseline and 12 months after AIT. The relationship between patients’ baseline immunological profiles and classification as low, high, and non-responders and between their sensitization profile to DP allergens and effectiveness were analyzed. Results: Of 141 patients recruited, 118 (mean [SD] age of 33.6 [9.5] years) were evaluable. One year after treatment, Der p 1-specific IgE, DP-specific IgG4, and IL-10 increased by a mean (SD) of 3.4 (13.6) kU/L (p = 0.016), 0.43 (0.55) mg/L (p < 0.0001), and 1.35 (7.56) pg/mL (p = 0.033), respectively. Non-responders showed increased baseline levels of IL-13 compared to high responders (p = 0.037). Changes in effectiveness variables between baseline and after AIT were similar regardless of the sensitization profile. Conclusion: Non-responsive patients to AIT showed increased baseline IL-13 concentrations, suggesting its value as prognostic biomarker. DP-specific AIT increased Der p 1-specific IgE, DP-specific IgG4, and IL-10 concentrations in patients with AR. All patients benefited from treatment regardless of their sensitization profile to major DP allergens. |
| first_indexed | 2024-12-22T00:26:58Z |
| format | Article |
| id | doaj.art-c6e680b1d03e4e3a8542e601745d2926 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-22T00:26:58Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-c6e680b1d03e4e3a8542e601745d29262022-12-21T18:45:02ZengElsevierWorld Allergy Organization Journal1939-45512021-06-01146100545Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapyJosé L. Justicia0Clara Padró1Albert Roger2Francisco Moreno3Manuel J. Rial4Antonio Parra5Antonio Valero6Alfons Malet7Aina Teniente8Anna Boronat9Carla Torán-Barona10Allergy Therapeutics Ibérica, Sant Joan Despí, Barcelona, Spain; Corresponding author.Allergy Department, Germans Trias i Pujol Hospital, Badalona, SpainAllergy Department, Germans Trias i Pujol Hospital, Badalona, SpainDr. Lobatón Clinic. Cádiz, SpainAllergy Department, Complexo Hospitalario Universitario A Coruña, A Coruña, SpainAllergy Department, Complexo Hospitalario Universitario A Coruña, A Coruña, SpainPneumonology and Respiratory Allergy, Hospital Clinic de Barcelona, IDIBAPS, CIBERES, Barcelona, SpainAl·lergo Centre, Barcelona, SpainImmunology Division, Germans Trias i Pujol Hospital, Badalona, Spain; Department of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Barcelona, SpainAllergy Therapeutics Ibérica, Sant Joan Despí, Barcelona, SpainAllergy Therapeutics Ibérica, Sant Joan Despí, Barcelona, SpainBackground: Despite the effectiveness of allergen immunotherapy (AIT), some patients are unresponsive for reasons still unknown; yet validated response biomarkers remain unavailable. Objective: To analyze immunological parameters as biomarkers to monitor and predict clinical response to a MicroCrystalline Tyrosine-adjuvanted house dust mite (HDM) AIT in patients with allergic rhinitis (AR). Methods: Observational, prospective, multicenter study including adult patients (aged 18–65 years) with AR, with and without asthma, sensitized to the HDM Dermatophagoides pteronyssinus (DP) and prescribed Acarovac Plus® DP 100% in the routine practice. Serum concentrations of total IgE, specific IgE, specific IgG4, IL-4, IL-5, IL-10, IL-13, and IFN-γ were compared between baseline and 12 months after AIT. The relationship between patients’ baseline immunological profiles and classification as low, high, and non-responders and between their sensitization profile to DP allergens and effectiveness were analyzed. Results: Of 141 patients recruited, 118 (mean [SD] age of 33.6 [9.5] years) were evaluable. One year after treatment, Der p 1-specific IgE, DP-specific IgG4, and IL-10 increased by a mean (SD) of 3.4 (13.6) kU/L (p = 0.016), 0.43 (0.55) mg/L (p < 0.0001), and 1.35 (7.56) pg/mL (p = 0.033), respectively. Non-responders showed increased baseline levels of IL-13 compared to high responders (p = 0.037). Changes in effectiveness variables between baseline and after AIT were similar regardless of the sensitization profile. Conclusion: Non-responsive patients to AIT showed increased baseline IL-13 concentrations, suggesting its value as prognostic biomarker. DP-specific AIT increased Der p 1-specific IgE, DP-specific IgG4, and IL-10 concentrations in patients with AR. All patients benefited from treatment regardless of their sensitization profile to major DP allergens.http://www.sciencedirect.com/science/article/pii/S1939455121000399House dust miteAllergic rhinitisSubcutaneous allergen immunotherapyMicrocrystalline TyrosineImmunological biomarkersSensitization profile |
| spellingShingle | José L. Justicia Clara Padró Albert Roger Francisco Moreno Manuel J. Rial Antonio Parra Antonio Valero Alfons Malet Aina Teniente Anna Boronat Carla Torán-Barona Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy World Allergy Organization Journal House dust mite Allergic rhinitis Subcutaneous allergen immunotherapy Microcrystalline Tyrosine Immunological biomarkers Sensitization profile |
| title | Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy |
| title_full | Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy |
| title_fullStr | Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy |
| title_full_unstemmed | Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy |
| title_short | Immunological parameters as biomarkers of response to MicroCrystalline Tyrosine-adjuvanted mite immunotherapy |
| title_sort | immunological parameters as biomarkers of response to microcrystalline tyrosine adjuvanted mite immunotherapy |
| topic | House dust mite Allergic rhinitis Subcutaneous allergen immunotherapy Microcrystalline Tyrosine Immunological biomarkers Sensitization profile |
| url | http://www.sciencedirect.com/science/article/pii/S1939455121000399 |
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