The Selection Of Hemofiltration Regimen In Sepsis
The results of a clinical trial using different high — volume hemofiltration regimens in surgical patients with sepsis is presented.Objective: improvement the clinical outcomes by inclusion the various regimens of a highvolume hemofiltration in the intensive therapy of patients with sepsis and septi...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2016-07-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1523 |
| _version_ | 1797874227645251584 |
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| author | A. N. Kudryavtsev V. V. Kulabukhov A. G. Chizhov |
| author_facet | A. N. Kudryavtsev V. V. Kulabukhov A. G. Chizhov |
| author_sort | A. N. Kudryavtsev |
| collection | DOAJ |
| description | The results of a clinical trial using different high — volume hemofiltration regimens in surgical patients with sepsis is presented.Objective: improvement the clinical outcomes by inclusion the various regimens of a highvolume hemofiltration in the intensive therapy of patients with sepsis and septic shock.Materials and methods: The study enrolled 46 patients. Twentyfour patients underwent intermittent very high volume hemofiltration (IHVH) with a replacement volume of 100 ml/kg/h for 4 hours and 22 patients were provided by continuous highvolume hemofiltration (CHVH) with an ultrafiltration dose of 50 ml/kg/h for 48 hours.Results. In the IHVH group, 28day mortality was 29,2% that was significantly differed from that in the CHVH group (40,9%). The investigation revealed that a body mass index of more than 25 kg/m2 was a contraindications to IHVH.Conclusion. There were positive changes in the patient's condition associated with the stabilization of the circulatory system and the normalization of the oxygentransport function. These changes persisted during and after the IHVH and were similarly observed in the CHVH group. Patients with high body weight (more than 25 kg/m2) required special blood flow velocity regimen (320—350 ml per minute). Maintaining fraction of filtration for less than 25% and preventing thrombosis hemofilter during IHVH was crucial for effective treatment. |
| first_indexed | 2024-04-10T01:28:40Z |
| format | Article |
| id | doaj.art-c6e6b7a8f9a34e9ea54cdce8747c578a |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:28:40Z |
| publishDate | 2016-07-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-c6e6b7a8f9a34e9ea54cdce8747c578a2023-03-13T09:32:54ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102016-07-01122435510.15360/1813-9779-2016-2-43-551501The Selection Of Hemofiltration Regimen In SepsisA. N. Kudryavtsev0V. V. Kulabukhov1A. G. Chizhov2Институт хирургии им. А. В. Вишневского Минздрава РоссииИнститут хирургии им. А. В. Вишневского Минздрава РоссииИнститут хирургии им. А. В. Вишневского Минздрава РоссииThe results of a clinical trial using different high — volume hemofiltration regimens in surgical patients with sepsis is presented.Objective: improvement the clinical outcomes by inclusion the various regimens of a highvolume hemofiltration in the intensive therapy of patients with sepsis and septic shock.Materials and methods: The study enrolled 46 patients. Twentyfour patients underwent intermittent very high volume hemofiltration (IHVH) with a replacement volume of 100 ml/kg/h for 4 hours and 22 patients were provided by continuous highvolume hemofiltration (CHVH) with an ultrafiltration dose of 50 ml/kg/h for 48 hours.Results. In the IHVH group, 28day mortality was 29,2% that was significantly differed from that in the CHVH group (40,9%). The investigation revealed that a body mass index of more than 25 kg/m2 was a contraindications to IHVH.Conclusion. There were positive changes in the patient's condition associated with the stabilization of the circulatory system and the normalization of the oxygentransport function. These changes persisted during and after the IHVH and were similarly observed in the CHVH group. Patients with high body weight (more than 25 kg/m2) required special blood flow velocity regimen (320—350 ml per minute). Maintaining fraction of filtration for less than 25% and preventing thrombosis hemofilter during IHVH was crucial for effective treatment.https://www.reanimatology.com/rmt/article/view/1523тяжелый сепсиссептический шоквысокообъемная гемофильтрациякомпоненты системы комплементадоза ультрафильтрациирежимы гемофильтрациисмертность |
| spellingShingle | A. N. Kudryavtsev V. V. Kulabukhov A. G. Chizhov The Selection Of Hemofiltration Regimen In Sepsis Общая реаниматология тяжелый сепсис септический шок высокообъемная гемофильтрация компоненты системы комплемента доза ультрафильтрации режимы гемофильтрации смертность |
| title | The Selection Of Hemofiltration Regimen In Sepsis |
| title_full | The Selection Of Hemofiltration Regimen In Sepsis |
| title_fullStr | The Selection Of Hemofiltration Regimen In Sepsis |
| title_full_unstemmed | The Selection Of Hemofiltration Regimen In Sepsis |
| title_short | The Selection Of Hemofiltration Regimen In Sepsis |
| title_sort | selection of hemofiltration regimen in sepsis |
| topic | тяжелый сепсис септический шок высокообъемная гемофильтрация компоненты системы комплемента доза ультрафильтрации режимы гемофильтрации смертность |
| url | https://www.reanimatology.com/rmt/article/view/1523 |
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