Comparative assessment of anti-cancer drugs against NUDT15 variants to prevent leucopenia side effect in leukemia patients

Comparative assessment of anti-cancer drugs against NUDT15 variants to prevent leucopenia side effect in leukemia patients

Abstract Background Human nucleotide triphosphate diphosphatase (NUDT15) is one of the essential proteins involved in the hydrolysis of anti-cancer drugs against leukemia. Polymorphisms in NUDT15 significantly affect the hydrolysis activity that leads to side effects, including leucopenia. Drugs hav...

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Bibliographic Details
Main Authors: Janakiraman V., Sudhan M., Khalaf F. Alsharif, Ibrahim F. Halawani, Shiek S. S. J. Ahmed, Shankargouda Patil
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
NUDT15
Leukemia
Drugs
Treatment
Docking
Simulation
Online Access:https://doi.org/10.1186/s43141-023-00538-1

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