Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition
With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.
Bibliographic Details
| Main Authors: |
Hannah J. Gleneadie,
Beatriz Fernandez-Ruiz,
Alessandro Sardini,
Mathew Van de Pette,
Andrew Dimond,
Rab K. Prinjha,
James McGinty,
Paul M. W. French,
Hakan Bagci,
Matthias Merkenschlager,
Amanda G. Fisher |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-03-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-023-04666-9
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