Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition
With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04666-9 |
| _version_ | 1827979399635402752 |
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| author | Hannah J. Gleneadie Beatriz Fernandez-Ruiz Alessandro Sardini Mathew Van de Pette Andrew Dimond Rab K. Prinjha James McGinty Paul M. W. French Hakan Bagci Matthias Merkenschlager Amanda G. Fisher |
| author_facet | Hannah J. Gleneadie Beatriz Fernandez-Ruiz Alessandro Sardini Mathew Van de Pette Andrew Dimond Rab K. Prinjha James McGinty Paul M. W. French Hakan Bagci Matthias Merkenschlager Amanda G. Fisher |
| author_sort | Hannah J. Gleneadie |
| collection | DOAJ |
| description | With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression. |
| first_indexed | 2024-04-09T21:37:14Z |
| format | Article |
| id | doaj.art-c6e9b4a0f39e4abeb7c2631bde5a7ad8 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-09T21:37:14Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-c6e9b4a0f39e4abeb7c2631bde5a7ad82023-03-26T11:15:59ZengNature PortfolioCommunications Biology2399-36422023-03-016111510.1038/s42003-023-04666-9Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibitionHannah J. Gleneadie0Beatriz Fernandez-Ruiz1Alessandro Sardini2Mathew Van de Pette3Andrew Dimond4Rab K. Prinjha5James McGinty6Paul M. W. French7Hakan Bagci8Matthias Merkenschlager9Amanda G. Fisher10Epigenetic Memory Group, MRC London Institute of Medical Sciences (LMS), Imperial College LondonEpigenetic Memory Group, MRC London Institute of Medical Sciences (LMS), Imperial College LondonWhole Animal Physiology and Imaging Facility, MRC LMS, Imperial College LondonEpigenetic Memory Group, MRC London Institute of Medical Sciences (LMS), Imperial College LondonEpigenetic Memory Group, MRC London Institute of Medical Sciences (LMS), Imperial College LondonImmunology and Epigenetics Research Unit, Research, GlaxoSmithKlinePhotonics Group, Department of Physics, Blackett Laboratory, Imperial College LondonPhotonics Group, Department of Physics, Blackett Laboratory, Imperial College LondonLymphocyte Development Group, MRC LMS, Imperial College LondonLymphocyte Development Group, MRC LMS, Imperial College LondonEpigenetic Memory Group, MRC London Institute of Medical Sciences (LMS), Imperial College LondonWith the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.https://doi.org/10.1038/s42003-023-04666-9 |
| spellingShingle | Hannah J. Gleneadie Beatriz Fernandez-Ruiz Alessandro Sardini Mathew Van de Pette Andrew Dimond Rab K. Prinjha James McGinty Paul M. W. French Hakan Bagci Matthias Merkenschlager Amanda G. Fisher Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition Communications Biology |
| title | Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition |
| title_full | Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition |
| title_fullStr | Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition |
| title_full_unstemmed | Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition |
| title_short | Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition |
| title_sort | endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon ezh2 and erk1 2 inhibition |
| url | https://doi.org/10.1038/s42003-023-04666-9 |
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