Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease

Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease

These studies explored the roles of receptor-mediated and bulk-phase endocytosis as well as macrophage infiltration in the accumulation of cholesterol in the mouse with Niemann-Pick type C (NPC) disease. Uptake of LDL-cholesterol varied from 514 μg/day in the liver to zero in the central nervous sys...

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Bibliographic Details
Main Authors: Benny Liu, Chonglun Xie, James A. Richardson, Stephen D. Turley, John M. Dietschy
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Journal of Lipid Research
Subjects:
hepatic dysfunction
lung failure
low density lipoprotein receptor
lysosomal cholesterol
apoptosis
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425076

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