Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Decidual remodelling of midluteal endometrium leads to a short implantation window after which the uterine mucosa either breaks down or is transformed into a robust matrix that accommodates the placenta throughout pregnancy. To gain insights into the underlying mechanisms, we established and charact...

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Bibliographic Details
Main Authors: Thomas M Rawlings, Komal Makwana, Deborah M Taylor, Matteo A Molè, Katherine J Fishwick, Maria Tryfonos, Joshua Odendaal, Amelia Hawkes, Magdalena Zernicka-Goetz, Geraldine M Hartshorne, Jan J Brosens, Emma S Lucas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
endometrium
embryo implantation
organoid
assembloid
senescence
decidualisation
Online Access:https://elifesciences.org/articles/69603

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