Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China
Xiaobing Tian,1,* Yan Li,2,3,* Jie Liu,1,2,4,5,* Qiuxing Lin,1,2,4,5 Qiaoxia Yang,6 Jun Tu,1,2,4,5 Jinghua Wang,1,2,4,5 Jidong Li,2,7 Xianjia Ning1,2,4,5 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Center of Cli...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-09-01
|
| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/epidemiology-of-isolated-impaired-glucose-tolerance-among-adults-aged--peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797936997842550784 |
|---|---|
| author | Tian X Li Y Liu J Lin Q Yang Q Tu J Wang J Li J Ning X |
| author_facet | Tian X Li Y Liu J Lin Q Yang Q Tu J Wang J Li J Ning X |
| author_sort | Tian X |
| collection | DOAJ |
| description | Xiaobing Tian,1,* Yan Li,2,3,* Jie Liu,1,2,4,5,* Qiuxing Lin,1,2,4,5 Qiaoxia Yang,6 Jun Tu,1,2,4,5 Jinghua Wang,1,2,4,5 Jidong Li,2,7 Xianjia Ning1,2,4,5 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Center of Clinical Epidemiology & Evidence-Based Medicine, The Jizhou People’s Hospital, Tianjin, People’s Republic of China; 3Department of Anesthesiology, The Jizhou People’s Hospital, Tianjin, People’s Republic of China; 4Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 5Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, People’s Republic of China; 6Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 7Department of Neurosurgery, The Jizhou People’s Hospital, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianjia Ning; Jidong Li Email xning@tmu.edu.cn; jd_li_doctor@163.comIntroduction: Isolated impaired glucose tolerance (i–IGT) is a subtype of prediabetes in which an individual demonstrates elevated 2-h post-glucose load glucose levels but normal fasting plasma glucose levels. However, few studies have explored the prevalence and risk factors of i–IGT among adults in rural China. Thus, we aimed to explore the prevalence and risk factors of i–IGT among adults ≥ 50 years old in a low-income, rural population in China.Materials and Methods: Individuals aged ≥ 50 years with normal fasting plasma glucose levels were included in the final analysis. Fasting and 2-h venous blood samples were collected to assess the selected parameter measurements.Results: A total of 2175 individuals were included in this study. The i–IGT prevalence was 22.9% and significantly higher among females than among males (P< 0.05). Older age [odds ratio (OR), 1.606; 95% confidence interval (CI), 1.101– 2.342; P=0.014), hypertension (OR, 1.554; 95% CI, 1.152– 2.019; P=0.004), and central obesity (OR, 1.395; 95% CI, 1.099– 1.771; P=0.006) were associated with i–IGT. Moreover, white blood cell (OR, 1.089; 95% CI, 1.009– 1.175; P=0.029), high-sensitivity C-reactive protein (OR, 1.049; 95% CI, 1.020– 1.078; P=0.001), serum uric acid (OR, 1.0003; 95% CI, 1.001– 1.004; P=0.001), triglyceride (OR, 1.540; 95% CI, 1.105– 2.147; P=0.011), and alanine aminotransferase (OR, 1.012; 95% CI, 1.004– 1.021; P=0.004) levels were also linked to i–IGT in the analyzed population.Conclusion: Health promotion education and a standardized approach to managing body weight, BP, and lipid and uric acid levels would benefit this low-income population in rural China for reducing the risk of cardiovascular disease.Keywords: impaired glucose tolerance, prevalence, risk factors, normal fasting plasma glucose, epidemiology |
| first_indexed | 2024-04-10T18:37:51Z |
| format | Article |
| id | doaj.art-c6ed5e778a7143c58caf64d6ceed3b9b |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:37:51Z |
| publishDate | 2021-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-c6ed5e778a7143c58caf64d6ceed3b9b2023-02-02T00:17:59ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072021-09-01Volume 144067407868917Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural ChinaTian XLi YLiu JLin QYang QTu JWang JLi JNing XXiaobing Tian,1,* Yan Li,2,3,* Jie Liu,1,2,4,5,* Qiuxing Lin,1,2,4,5 Qiaoxia Yang,6 Jun Tu,1,2,4,5 Jinghua Wang,1,2,4,5 Jidong Li,2,7 Xianjia Ning1,2,4,5 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Center of Clinical Epidemiology & Evidence-Based Medicine, The Jizhou People’s Hospital, Tianjin, People’s Republic of China; 3Department of Anesthesiology, The Jizhou People’s Hospital, Tianjin, People’s Republic of China; 4Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 5Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, People’s Republic of China; 6Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 7Department of Neurosurgery, The Jizhou People’s Hospital, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianjia Ning; Jidong Li Email xning@tmu.edu.cn; jd_li_doctor@163.comIntroduction: Isolated impaired glucose tolerance (i–IGT) is a subtype of prediabetes in which an individual demonstrates elevated 2-h post-glucose load glucose levels but normal fasting plasma glucose levels. However, few studies have explored the prevalence and risk factors of i–IGT among adults in rural China. Thus, we aimed to explore the prevalence and risk factors of i–IGT among adults ≥ 50 years old in a low-income, rural population in China.Materials and Methods: Individuals aged ≥ 50 years with normal fasting plasma glucose levels were included in the final analysis. Fasting and 2-h venous blood samples were collected to assess the selected parameter measurements.Results: A total of 2175 individuals were included in this study. The i–IGT prevalence was 22.9% and significantly higher among females than among males (P< 0.05). Older age [odds ratio (OR), 1.606; 95% confidence interval (CI), 1.101– 2.342; P=0.014), hypertension (OR, 1.554; 95% CI, 1.152– 2.019; P=0.004), and central obesity (OR, 1.395; 95% CI, 1.099– 1.771; P=0.006) were associated with i–IGT. Moreover, white blood cell (OR, 1.089; 95% CI, 1.009– 1.175; P=0.029), high-sensitivity C-reactive protein (OR, 1.049; 95% CI, 1.020– 1.078; P=0.001), serum uric acid (OR, 1.0003; 95% CI, 1.001– 1.004; P=0.001), triglyceride (OR, 1.540; 95% CI, 1.105– 2.147; P=0.011), and alanine aminotransferase (OR, 1.012; 95% CI, 1.004– 1.021; P=0.004) levels were also linked to i–IGT in the analyzed population.Conclusion: Health promotion education and a standardized approach to managing body weight, BP, and lipid and uric acid levels would benefit this low-income population in rural China for reducing the risk of cardiovascular disease.Keywords: impaired glucose tolerance, prevalence, risk factors, normal fasting plasma glucose, epidemiologyhttps://www.dovepress.com/epidemiology-of-isolated-impaired-glucose-tolerance-among-adults-aged--peer-reviewed-fulltext-article-DMSOimpaired glucose toleranceprevalencerisk factorsnormal fasting plasma glucoseepidemiology |
| spellingShingle | Tian X Li Y Liu J Lin Q Yang Q Tu J Wang J Li J Ning X Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China Diabetes, Metabolic Syndrome and Obesity impaired glucose tolerance prevalence risk factors normal fasting plasma glucose epidemiology |
| title | Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China |
| title_full | Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China |
| title_fullStr | Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China |
| title_full_unstemmed | Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China |
| title_short | Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China |
| title_sort | epidemiology of isolated impaired glucose tolerance among adults aged above 50 years in rural china |
| topic | impaired glucose tolerance prevalence risk factors normal fasting plasma glucose epidemiology |
| url | https://www.dovepress.com/epidemiology-of-isolated-impaired-glucose-tolerance-among-adults-aged--peer-reviewed-fulltext-article-DMSO |
| work_keys_str_mv | AT tianx epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT liy epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT liuj epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT linq epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT yangq epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT tuj epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT wangj epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT lij epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina AT ningx epidemiologyofisolatedimpairedglucosetoleranceamongadultsagedabove50yearsinruralchina |