Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal
Cancers evolve from normal tissues and share an endogenous regulatory realm distinctive from that of normal human tissues. Unearthing such an endogenous realm faces challenges due to heterogeneous biology data. This study computes petabyte level data and reveals the endogenous regulatory networks of...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037022001325 |
| _version_ | 1797978242255159296 |
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| author | Anyou Wang |
| author_facet | Anyou Wang |
| author_sort | Anyou Wang |
| collection | DOAJ |
| description | Cancers evolve from normal tissues and share an endogenous regulatory realm distinctive from that of normal human tissues. Unearthing such an endogenous realm faces challenges due to heterogeneous biology data. This study computes petabyte level data and reveals the endogenous regulatory networks of normal and cancers and then unearths the most important endogenous regulators for normal and cancerous realm. In normal, proteins dominate the entire realm and trans-regulate their targets across chromosomes and ribosomal proteins serve as the most important drivers. However, in cancerous realm, noncoding RNAs dominate the whole realm and pseudogenes work as the most important regulators that cis-regulate their neighbors, in which they primarily regulate their targets within 1 million base pairs but they rarely regulate their cognates with complementary sequences as thought. Therefore, two distinctive mechanisms rule the normal and cancerous realm separately, in which noncoding RNAs endogenously regulate cancers, instead of proteins as currently conceptualized. This establishes a fundamental avenue to understand the basis of cancerous and normal physiology. |
| first_indexed | 2024-04-11T05:19:53Z |
| format | Article |
| id | doaj.art-c6eda968ddec41b5bae761e15549f0f2 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-04-11T05:19:53Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-c6eda968ddec41b5bae761e15549f0f22022-12-24T04:52:05ZengElsevierComputational and Structural Biotechnology Journal2001-03702022-01-012019351945Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normalAnyou Wang0The Institute for Integrative Genome Biology, University of California at Riverside, Riverside, CA 92521, USACancers evolve from normal tissues and share an endogenous regulatory realm distinctive from that of normal human tissues. Unearthing such an endogenous realm faces challenges due to heterogeneous biology data. This study computes petabyte level data and reveals the endogenous regulatory networks of normal and cancers and then unearths the most important endogenous regulators for normal and cancerous realm. In normal, proteins dominate the entire realm and trans-regulate their targets across chromosomes and ribosomal proteins serve as the most important drivers. However, in cancerous realm, noncoding RNAs dominate the whole realm and pseudogenes work as the most important regulators that cis-regulate their neighbors, in which they primarily regulate their targets within 1 million base pairs but they rarely regulate their cognates with complementary sequences as thought. Therefore, two distinctive mechanisms rule the normal and cancerous realm separately, in which noncoding RNAs endogenously regulate cancers, instead of proteins as currently conceptualized. This establishes a fundamental avenue to understand the basis of cancerous and normal physiology.http://www.sciencedirect.com/science/article/pii/S2001037022001325Noncoding RNACancerRegulatory networkSystemsEndogenousFINET |
| spellingShingle | Anyou Wang Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal Computational and Structural Biotechnology Journal Noncoding RNA Cancer Regulatory network Systems Endogenous FINET |
| title | Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal |
| title_full | Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal |
| title_fullStr | Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal |
| title_full_unstemmed | Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal |
| title_short | Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal |
| title_sort | noncoding rnas endogenously rule the cancerous regulatory realm while proteins govern the normal |
| topic | Noncoding RNA Cancer Regulatory network Systems Endogenous FINET |
| url | http://www.sciencedirect.com/science/article/pii/S2001037022001325 |
| work_keys_str_mv | AT anyouwang noncodingrnasendogenouslyrulethecancerousregulatoryrealmwhileproteinsgovernthenormal |