Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/β-catenin pathway

Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/β-catenin pathway

The therapeutic efficacy of umbilical cord mesenchymal stem cells (UCMSCs) in acute respiratory distress syndrome (ARDS) is mainly limited by the efficiency of homing of UCMSCs toward tissue damage. C-X-C chemokine receptor type 7 (CXCR7), which is involved in the mobilization of UCMSCs, is only exp...

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Bibliographic Details
Main Authors: Kun Xiao, Chang Liu, Heming Wang, Fei Hou, Yinghan Shi, Zhi Rong Qian, Hao Zhang, David Y.B. Deng, Lixin Xie
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acute respiratory distress syndrome
C-X-C chemokine receptor type 7
Lung fibrosis
Umbilical cord mesenchymal stem cells
Homing effect of stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223009150

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