Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway
Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from <i>Datura metel</i> L.; are the main effective components for the treatment of psoriasis. However, the precise mec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/14/2596 |
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| author | Tingting Li Zheng Wei Yanping Sun Qiuhong Wang Haixue Kuang |
| author_facet | Tingting Li Zheng Wei Yanping Sun Qiuhong Wang Haixue Kuang |
| author_sort | Tingting Li |
| collection | DOAJ |
| description | Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from <i>Datura metel</i> L.; are the main effective components for the treatment of psoriasis. However, the precise mechanisms of action of withanolides for the treatment of psoriasis remain unclear. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia and inflammatory cell infiltration in the effective skin of model mice. In addition, we also found that withanolides suppressed the activation of STAT3, ERK1/2 and P38 signaling pathways in IMQ-stimulated HaCat cells. These results suggest that withanolides possess an anti-inflammatory effect and have significant therapeutic potential for the prevention and treatment of psoriasis. |
| first_indexed | 2024-12-13T01:41:09Z |
| format | Article |
| id | doaj.art-c6ee996c6de6474c8a92bc0f291bf499 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T01:41:09Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c6ee996c6de6474c8a92bc0f291bf4992022-12-22T00:03:45ZengMDPI AGMolecules1420-30492019-07-012414259610.3390/molecules24142596molecules24142596Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 PathwayTingting Li0Zheng Wei1Yanping Sun2Qiuhong Wang3Haixue Kuang4Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 280 Outer Ring Road, University Town, Guangzhou 510006, ChinaKey Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, ChinaPsoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from <i>Datura metel</i> L.; are the main effective components for the treatment of psoriasis. However, the precise mechanisms of action of withanolides for the treatment of psoriasis remain unclear. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia and inflammatory cell infiltration in the effective skin of model mice. In addition, we also found that withanolides suppressed the activation of STAT3, ERK1/2 and P38 signaling pathways in IMQ-stimulated HaCat cells. These results suggest that withanolides possess an anti-inflammatory effect and have significant therapeutic potential for the prevention and treatment of psoriasis.https://www.mdpi.com/1420-3049/24/14/2596psoriasiswithanolides<i>Datura metel</i> L.imiquimodinflammation |
| spellingShingle | Tingting Li Zheng Wei Yanping Sun Qiuhong Wang Haixue Kuang Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway Molecules psoriasis withanolides <i>Datura metel</i> L. imiquimod inflammation |
| title | Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway |
| title_full | Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway |
| title_fullStr | Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway |
| title_full_unstemmed | Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway |
| title_short | Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway |
| title_sort | withanolides extracted from datura metel l inhibit keratinocyte proliferation and imiquimod induced psoriasis like dermatitis via the stat3 p38 erk1 2 pathway |
| topic | psoriasis withanolides <i>Datura metel</i> L. imiquimod inflammation |
| url | https://www.mdpi.com/1420-3049/24/14/2596 |
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