Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI
Abstract Background Crohn’s disease (CD) is an inflammatory disease of the gastrointestinal tract. The disease behavior changes over time, and endoscopy is crucial in evaluating and monitoring the course of CD. To reduce the economic burden of patients and alleviate the discomfort associated with in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-02-01
|
| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13244-024-01628-5 |
| _version_ | 1797274401584971776 |
|---|---|
| author | Wenjuan Wu Yan Jin Dongyang Zhu Junqing Wang Yue Cheng Lei Zhang |
| author_facet | Wenjuan Wu Yan Jin Dongyang Zhu Junqing Wang Yue Cheng Lei Zhang |
| author_sort | Wenjuan Wu |
| collection | DOAJ |
| description | Abstract Background Crohn’s disease (CD) is an inflammatory disease of the gastrointestinal tract. The disease behavior changes over time, and endoscopy is crucial in evaluating and monitoring the course of CD. To reduce the economic burden of patients and alleviate the discomfort associated with ineffective examination, it is necessary to fully understand the location, extent, and severity of intestinal stenosis in patients with CD before endoscopy. This study aimed to utilize imaging features of magnetic resonance enterography (MRE) to evaluate intestinal stenosis in patients with CD and to predict whether endoscopy could be passed. Methods MRE data of patients with CD were collected, while age, gender, disease duration, and laboratory test parameters were also gathered. Two radiologists analyzed the images and assessed whether endoscopy could be passed based on the imaging performance. Imaging features of MRE were analyzed in groups based on endoscopy results. Results The readers evaluated the imaging performance for 86 patients to determine if endoscopy could be passed and performed a consistency test (compared between two readers k = 0.812, p = 0.000). In the univariate analysis, statistical differences were observed in the degree of T1WI enhancement, thickness of the intestine wall at the stenosis, and diameter of the upstream intestine between the two groups of whether endoscopy was passed. In multivariate logistic regression, the diameter of the upstream intestine was identified to be an independent factor in predicting whether endoscopy was passed or not (OR = 3.260, p = 0.046). Conclusions The utilization of MRE signs for assessing the passage of an endoscope through the narrow segment revealed that the diameter of the upstream intestine emerged as an independent predictor of endoscopic passage. Before performing an endoscopy, MRE can aid in evaluating the passage of the endoscope. Critical relevance statement This retrospective study explored the imaging features of MRE to evaluate intestinal stenosis in patients with Crohn’s disease and determined that the diameter of the upstream intestine of the stenotic segment was an independent predictor in assessing endoscopic passage. Key points • Endoscopy is crucial in evaluating and monitoring the course of Crohn’s disease. • The diameter of the upstream intestine of the stenotic segment was an independent predictor in assessing endoscopic passage. • MRE can aid in evaluating the passage of the endoscope in stenotic segments of Crohn’s disease. Graphical Abstract |
| first_indexed | 2024-03-07T14:57:48Z |
| format | Article |
| id | doaj.art-c6ef0e528a9542ae845cdbb51387c253 |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-03-07T14:57:48Z |
| publishDate | 2024-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-c6ef0e528a9542ae845cdbb51387c2532024-03-05T19:20:08ZengSpringerOpenInsights into Imaging1869-41012024-02-011511910.1186/s13244-024-01628-5Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRIWenjuan Wu0Yan Jin1Dongyang Zhu2Junqing Wang3Yue Cheng4Lei Zhang5Department of Radiology, Wuxi Second People’s Hospital, Jiangnan University Medical CenterDepartment of Gastroenterology, Wuxi Second People’s Hospital, Jiangnan University Medical CenterDepartment of Radiology, Wuxi Second People’s Hospital, Jiangnan University Medical CenterDepartment of Radiology, Wuxi Second People’s Hospital, Jiangnan University Medical CenterDepartment of Radiology, Wuxi Second People’s Hospital, Jiangnan University Medical CenterDepartment of Radiology, Wuxi Second People’s Hospital, Jiangnan University Medical CenterAbstract Background Crohn’s disease (CD) is an inflammatory disease of the gastrointestinal tract. The disease behavior changes over time, and endoscopy is crucial in evaluating and monitoring the course of CD. To reduce the economic burden of patients and alleviate the discomfort associated with ineffective examination, it is necessary to fully understand the location, extent, and severity of intestinal stenosis in patients with CD before endoscopy. This study aimed to utilize imaging features of magnetic resonance enterography (MRE) to evaluate intestinal stenosis in patients with CD and to predict whether endoscopy could be passed. Methods MRE data of patients with CD were collected, while age, gender, disease duration, and laboratory test parameters were also gathered. Two radiologists analyzed the images and assessed whether endoscopy could be passed based on the imaging performance. Imaging features of MRE were analyzed in groups based on endoscopy results. Results The readers evaluated the imaging performance for 86 patients to determine if endoscopy could be passed and performed a consistency test (compared between two readers k = 0.812, p = 0.000). In the univariate analysis, statistical differences were observed in the degree of T1WI enhancement, thickness of the intestine wall at the stenosis, and diameter of the upstream intestine between the two groups of whether endoscopy was passed. In multivariate logistic regression, the diameter of the upstream intestine was identified to be an independent factor in predicting whether endoscopy was passed or not (OR = 3.260, p = 0.046). Conclusions The utilization of MRE signs for assessing the passage of an endoscope through the narrow segment revealed that the diameter of the upstream intestine emerged as an independent predictor of endoscopic passage. Before performing an endoscopy, MRE can aid in evaluating the passage of the endoscope. Critical relevance statement This retrospective study explored the imaging features of MRE to evaluate intestinal stenosis in patients with Crohn’s disease and determined that the diameter of the upstream intestine of the stenotic segment was an independent predictor in assessing endoscopic passage. Key points • Endoscopy is crucial in evaluating and monitoring the course of Crohn’s disease. • The diameter of the upstream intestine of the stenotic segment was an independent predictor in assessing endoscopic passage. • MRE can aid in evaluating the passage of the endoscope in stenotic segments of Crohn’s disease. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01628-5Crohn diseaseMagnetic resonance enterographyEndoscopyStenosisEndoscopic passage |
| spellingShingle | Wenjuan Wu Yan Jin Dongyang Zhu Junqing Wang Yue Cheng Lei Zhang Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI Insights into Imaging Crohn disease Magnetic resonance enterography Endoscopy Stenosis Endoscopic passage |
| title | Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI |
| title_full | Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI |
| title_fullStr | Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI |
| title_full_unstemmed | Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI |
| title_short | Assessment of intestinal luminal stenosis and prediction of endoscopy passage in Crohn’s disease patients using MRI |
| title_sort | assessment of intestinal luminal stenosis and prediction of endoscopy passage in crohn s disease patients using mri |
| topic | Crohn disease Magnetic resonance enterography Endoscopy Stenosis Endoscopic passage |
| url | https://doi.org/10.1186/s13244-024-01628-5 |
| work_keys_str_mv | AT wenjuanwu assessmentofintestinalluminalstenosisandpredictionofendoscopypassageincrohnsdiseasepatientsusingmri AT yanjin assessmentofintestinalluminalstenosisandpredictionofendoscopypassageincrohnsdiseasepatientsusingmri AT dongyangzhu assessmentofintestinalluminalstenosisandpredictionofendoscopypassageincrohnsdiseasepatientsusingmri AT junqingwang assessmentofintestinalluminalstenosisandpredictionofendoscopypassageincrohnsdiseasepatientsusingmri AT yuecheng assessmentofintestinalluminalstenosisandpredictionofendoscopypassageincrohnsdiseasepatientsusingmri AT leizhang assessmentofintestinalluminalstenosisandpredictionofendoscopypassageincrohnsdiseasepatientsusingmri |