Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator

Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator

Abstract A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on the exposures of CYP3A4, CYP2C8, and CYP2B6 substrat...

Full description

Bibliographic Details
Main Authors: Kun Wang, Xueting Yao, Miao Zhang, Dongyang Liu, Yuying Gao, Srikumar Sahasranaman, Ying C. Ou
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12605

Similar Items

Similar Items