Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis
Cardiac amyloidosis (CA) is a heterogeneous group of diseases in which extracellular insoluble amyloid proteins are deposited in specific organs and tissues locally or systemically, thereby interfering with physiological function. Transthyretin protein (TTR) and light chain (AL) amyloidosis are the...
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MDPI AG
2022-09-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/10/1395 |
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| author | Min Zhao Raffaella Calabretta Josef Yu Patrick Binder Shuo Hu Marcus Hacker Xiang Li |
| author_facet | Min Zhao Raffaella Calabretta Josef Yu Patrick Binder Shuo Hu Marcus Hacker Xiang Li |
| author_sort | Min Zhao |
| collection | DOAJ |
| description | Cardiac amyloidosis (CA) is a heterogeneous group of diseases in which extracellular insoluble amyloid proteins are deposited in specific organs and tissues locally or systemically, thereby interfering with physiological function. Transthyretin protein (TTR) and light chain (AL) amyloidosis are the most common types of cardiac amyloidosis. Radionuclide bone scintigraphy has recently become the most common non-invasive test for the diagnosis of TTR-CA but is of limited value for the diagnosis of AL-CA. PET has proved promising for the diagnosis of CA and its applications are expected to expand in the future. This review summarizes the current bone scintigraphy and amyloid-targeting Positron emission tomography (PET) imaging, the binding imaging properties of radiotracers, and the values of diagnosis, prognosis, and monitoring therapy response in CA. |
| first_indexed | 2024-03-09T20:41:09Z |
| format | Article |
| id | doaj.art-c6f013e7a9bf4225a44394d5e0b7305a |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T20:41:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-c6f013e7a9bf4225a44394d5e0b7305a2023-11-23T22:58:52ZengMDPI AGBiology2079-77372022-09-011110139510.3390/biology11101395Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac AmyloidosisMin Zhao0Raffaella Calabretta1Josef Yu2Patrick Binder3Shuo Hu4Marcus Hacker5Xiang Li6Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, ChinaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, Floor 3L, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, Floor 3L, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, Floor 3L, 1090 Vienna, AustriaDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, ChinaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, Floor 3L, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, Floor 3L, 1090 Vienna, AustriaCardiac amyloidosis (CA) is a heterogeneous group of diseases in which extracellular insoluble amyloid proteins are deposited in specific organs and tissues locally or systemically, thereby interfering with physiological function. Transthyretin protein (TTR) and light chain (AL) amyloidosis are the most common types of cardiac amyloidosis. Radionuclide bone scintigraphy has recently become the most common non-invasive test for the diagnosis of TTR-CA but is of limited value for the diagnosis of AL-CA. PET has proved promising for the diagnosis of CA and its applications are expected to expand in the future. This review summarizes the current bone scintigraphy and amyloid-targeting Positron emission tomography (PET) imaging, the binding imaging properties of radiotracers, and the values of diagnosis, prognosis, and monitoring therapy response in CA.https://www.mdpi.com/2079-7737/11/10/1395cardiac amyloidosisbone scintigraphySPECT/CTPETdiagnosistherapy response |
| spellingShingle | Min Zhao Raffaella Calabretta Josef Yu Patrick Binder Shuo Hu Marcus Hacker Xiang Li Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis Biology cardiac amyloidosis bone scintigraphy SPECT/CT PET diagnosis therapy response |
| title | Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis |
| title_full | Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis |
| title_fullStr | Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis |
| title_full_unstemmed | Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis |
| title_short | Nuclear Molecular Imaging of Disease Burden and Response to Treatment for Cardiac Amyloidosis |
| title_sort | nuclear molecular imaging of disease burden and response to treatment for cardiac amyloidosis |
| topic | cardiac amyloidosis bone scintigraphy SPECT/CT PET diagnosis therapy response |
| url | https://www.mdpi.com/2079-7737/11/10/1395 |
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