FADD as a key molecular player in cancer progression
Abstract Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remains a major global public health problem. Cancer pathogenesis is extremely intricate and largely unknown. Fas-associated protein with death domain (FADD) was initially ide...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-022-00560-y |
| _version_ | 1798018413628489728 |
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| author | Ying Liu Xiaoge Li Xuehao Zhou Jianxun Wang Xiang Ao |
| author_facet | Ying Liu Xiaoge Li Xuehao Zhou Jianxun Wang Xiang Ao |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | Abstract Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remains a major global public health problem. Cancer pathogenesis is extremely intricate and largely unknown. Fas-associated protein with death domain (FADD) was initially identified as an adaptor protein for death receptor-mediated extrinsic apoptosis. Recent evidence suggests that FADD plays a vital role in non-apoptotic cellular processes, such as proliferation, autophagy, and necroptosis. FADD expression and activity of are modulated by a complicated network of processes, such as DNA methylation, non-coding RNA, and post-translational modification. FADD dysregulation has been shown to be closely associated with the pathogenesis of numerous types of cancer. However, the detailed mechanisms of FADD dysregulation involved in cancer progression are still not fully understood. This review mainly summarizes recent findings on the structure, functions, and regulatory mechanisms of FADD and focuses on its role in cancer progression. The clinical implications of FADD as a biomarker and therapeutic target for cancer patients are also discussed. The information reviewed herein may expand researchers’ understanding of FADD and contribute to the development of FADD-based therapeutic strategies for cancer patients. |
| first_indexed | 2024-04-11T16:23:47Z |
| format | Article |
| id | doaj.art-c6f05ba9d8cd4ff1b428b22e6e24592c |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-04-11T16:23:47Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-c6f05ba9d8cd4ff1b428b22e6e24592c2022-12-22T04:14:16ZengBMCMolecular Medicine1076-15511528-36582022-11-0128111910.1186/s10020-022-00560-yFADD as a key molecular player in cancer progressionYing Liu0Xiaoge Li1Xuehao Zhou2Jianxun Wang3Xiang Ao4Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao UniversitySchool of Basic Medical Sciences, Qingdao Medical College, Qingdao UniversitySchool of Basic Medical Sciences, Qingdao Medical College, Qingdao UniversitySchool of Basic Medical Sciences, Qingdao Medical College, Qingdao UniversityInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao UniversityAbstract Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remains a major global public health problem. Cancer pathogenesis is extremely intricate and largely unknown. Fas-associated protein with death domain (FADD) was initially identified as an adaptor protein for death receptor-mediated extrinsic apoptosis. Recent evidence suggests that FADD plays a vital role in non-apoptotic cellular processes, such as proliferation, autophagy, and necroptosis. FADD expression and activity of are modulated by a complicated network of processes, such as DNA methylation, non-coding RNA, and post-translational modification. FADD dysregulation has been shown to be closely associated with the pathogenesis of numerous types of cancer. However, the detailed mechanisms of FADD dysregulation involved in cancer progression are still not fully understood. This review mainly summarizes recent findings on the structure, functions, and regulatory mechanisms of FADD and focuses on its role in cancer progression. The clinical implications of FADD as a biomarker and therapeutic target for cancer patients are also discussed. The information reviewed herein may expand researchers’ understanding of FADD and contribute to the development of FADD-based therapeutic strategies for cancer patients.https://doi.org/10.1186/s10020-022-00560-yFADDInflammationDrug resistanceBiomarkerTherapeutic target |
| spellingShingle | Ying Liu Xiaoge Li Xuehao Zhou Jianxun Wang Xiang Ao FADD as a key molecular player in cancer progression Molecular Medicine FADD Inflammation Drug resistance Biomarker Therapeutic target |
| title | FADD as a key molecular player in cancer progression |
| title_full | FADD as a key molecular player in cancer progression |
| title_fullStr | FADD as a key molecular player in cancer progression |
| title_full_unstemmed | FADD as a key molecular player in cancer progression |
| title_short | FADD as a key molecular player in cancer progression |
| title_sort | fadd as a key molecular player in cancer progression |
| topic | FADD Inflammation Drug resistance Biomarker Therapeutic target |
| url | https://doi.org/10.1186/s10020-022-00560-y |
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