Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study
Background: Chemokines are pro-inflammatory cells that can be induced during an immune response to recruit cells of the immune system to a site of infection. Aim: This study was conducted to detect the presence of chemokines, macrophage inflammatory protein-1α (MIP-1α), and 1β (MIP-1β) and estimate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Contemporary Clinical Dentistry |
| Subjects: | |
| Online Access: | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2016;volume=7;issue=3;spage=302;epage=306;aulast=Kumar |
| _version_ | 1818204345701761024 |
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| author | Naveen Kommineni Kumar Veera Kishore Kasa Reddy Prathyusha Padakandla Harshini Togaru Swathi Kalagatla Vinay Chand M Reddy |
| author_facet | Naveen Kommineni Kumar Veera Kishore Kasa Reddy Prathyusha Padakandla Harshini Togaru Swathi Kalagatla Vinay Chand M Reddy |
| author_sort | Naveen Kommineni Kumar |
| collection | DOAJ |
| description | Background: Chemokines are pro-inflammatory cells that can be induced during an immune response to recruit cells of the immune system to a site of infection. Aim: This study was conducted to detect the presence of chemokines, macrophage inflammatory protein-1α (MIP-1α), and 1β (MIP-1β) and estimate their levels in gingival crevicular fluid (GCF) in children with band and loop space maintainers. Materials and Methods: MIP-1α and MIP-1β levels were estimated in GCF samples from twenty healthy children and twenty children with band and loop space maintainers. Periodontal status was evaluated by measuring gingival index, plaque index, and Russell′s periodontal index. The GCF samples were quantified by ELISA, and the levels of MIP-1α and MIP-1β were determined. Results: The mean MIP-1α concentrations in healthy children and those with space maintainers were 395.75 pg/µl and 857.85 pg/µl, respectively, and MIP-1β was 342.55 pg/µl and 685.25 pg/µl, respectively. MIP-1α and MIP-1β levels in GCF from children with space maintainers were significantly higher than in the healthy group, and statistically significant difference existed between these two groups. Conclusion: MIP-1α and MIP-1β can be considered as novel biomarkers in the biological mechanism underlying the pathogenesis of gingival inflammation in children with space maintainers. |
| first_indexed | 2024-12-12T03:39:46Z |
| format | Article |
| id | doaj.art-c6f0b08dd5de46aab5ee0612d62f4bb7 |
| institution | Directory Open Access Journal |
| issn | 0976-237X 0976-2361 |
| language | English |
| last_indexed | 2024-12-12T03:39:46Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Contemporary Clinical Dentistry |
| spelling | doaj.art-c6f0b08dd5de46aab5ee0612d62f4bb72022-12-22T00:39:42ZengWolters Kluwer Medknow PublicationsContemporary Clinical Dentistry0976-237X0976-23612016-01-017330230610.4103/0976-237X.188542Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical studyNaveen Kommineni KumarVeera Kishore Kasa ReddyPrathyusha PadakandlaHarshini TogaruSwathi KalagatlaVinay Chand M ReddyBackground: Chemokines are pro-inflammatory cells that can be induced during an immune response to recruit cells of the immune system to a site of infection. Aim: This study was conducted to detect the presence of chemokines, macrophage inflammatory protein-1α (MIP-1α), and 1β (MIP-1β) and estimate their levels in gingival crevicular fluid (GCF) in children with band and loop space maintainers. Materials and Methods: MIP-1α and MIP-1β levels were estimated in GCF samples from twenty healthy children and twenty children with band and loop space maintainers. Periodontal status was evaluated by measuring gingival index, plaque index, and Russell′s periodontal index. The GCF samples were quantified by ELISA, and the levels of MIP-1α and MIP-1β were determined. Results: The mean MIP-1α concentrations in healthy children and those with space maintainers were 395.75 pg/µl and 857.85 pg/µl, respectively, and MIP-1β was 342.55 pg/µl and 685.25 pg/µl, respectively. MIP-1α and MIP-1β levels in GCF from children with space maintainers were significantly higher than in the healthy group, and statistically significant difference existed between these two groups. Conclusion: MIP-1α and MIP-1β can be considered as novel biomarkers in the biological mechanism underlying the pathogenesis of gingival inflammation in children with space maintainers.http://www.contempclindent.org/article.asp?issn=0976-237X;year=2016;volume=7;issue=3;spage=302;epage=306;aulast=KumarBand and loop space maintainerschemokinesgingival crevicular fluidinflammationmacrophage inflammatory protein-1αmacrophage inflammatory protein-1β |
| spellingShingle | Naveen Kommineni Kumar Veera Kishore Kasa Reddy Prathyusha Padakandla Harshini Togaru Swathi Kalagatla Vinay Chand M Reddy Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study Contemporary Clinical Dentistry Band and loop space maintainers chemokines gingival crevicular fluid inflammation macrophage inflammatory protein-1α macrophage inflammatory protein-1β |
| title | Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study |
| title_full | Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study |
| title_fullStr | Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study |
| title_full_unstemmed | Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study |
| title_short | Evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers: A clinico-biochemical study |
| title_sort | evaluation of chemokines in gingival crevicular fluid in children with band and loop space maintainers a clinico biochemical study |
| topic | Band and loop space maintainers chemokines gingival crevicular fluid inflammation macrophage inflammatory protein-1α macrophage inflammatory protein-1β |
| url | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2016;volume=7;issue=3;spage=302;epage=306;aulast=Kumar |
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