Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed...

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Bibliographic Details
Main Authors: Ao Li, Dan You, Wenyan Li, Yingjie Cui, Yingzi He, Wen Li, Yan Chen, Xiao Feng, Shan Sun, Renjie Chai, Huawei Li
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
apoptosis
gentamycin
h3k4me2
hair cell
compounds
Online Access:http://dx.doi.org/10.1080/10717544.2018.1461277

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