Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease
Abstract Background Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in vivo. Method Two hundred and twenty‐one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impai...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12154 |
| _version_ | 1811231999112773632 |
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| author | Cécile Tissot Joseph Therriault Tharick A. Pascoal Mira Chamoun Firoza Z. Lussier Melissa Savard Sulantha S. Mathotaarachchi Andréa L. Benedet Emilie M. Thomas Marlee Parsons Ziad Nasreddine Pedro Rosa‐Neto Serge Gauthier |
| author_facet | Cécile Tissot Joseph Therriault Tharick A. Pascoal Mira Chamoun Firoza Z. Lussier Melissa Savard Sulantha S. Mathotaarachchi Andréa L. Benedet Emilie M. Thomas Marlee Parsons Ziad Nasreddine Pedro Rosa‐Neto Serge Gauthier |
| author_sort | Cécile Tissot |
| collection | DOAJ |
| description | Abstract Background Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in vivo. Method Two hundred and twenty‐one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impairment, and 26 AD) underwent [18F]MK6240‐tau‐positron emission tomography (PET), [18F]AZD4694‐amyloid‐PET, magnetic resonance imaging, and neuropsychological evaluations. Spearman correlations and voxel‐based regression models evaluated the relationship between Neuropsychiatric Inventory Questionnaire (NPI‐Q) scores, and tau‐PET, amyloid‐PET, and voxel‐based morphometry. Results Fifty percent of individuals presented NPS; these correlated with tau, not amyloid beta or neurodegeneration. Associations between NPI‐Q score and tau‐PET were stronger in the parietal association area, superior frontal, temporal, and medial occipital lobes. NPI‐Q domains associated with distinct patterns of tau uptake. Conclusions NPS are predominantly related to tau in aging and dementia. Regions affected are part of the behavioral circuits, and vulnerable to early AD pathology. Domain‐specific analyses showed NPS are related to the AD pathophysiological processes in a symptom‐specific manner. |
| first_indexed | 2024-04-12T10:54:35Z |
| format | Article |
| id | doaj.art-c6f16b7bf69f4bb5be69c17f10b39e75 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-12T10:54:35Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-c6f16b7bf69f4bb5be69c17f10b39e752022-12-22T03:36:07ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372021-01-0171n/an/a10.1002/trc2.12154Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's diseaseCécile Tissot0Joseph Therriault1Tharick A. Pascoal2Mira Chamoun3Firoza Z. Lussier4Melissa Savard5Sulantha S. Mathotaarachchi6Andréa L. Benedet7Emilie M. Thomas8Marlee Parsons9Ziad Nasreddine10Pedro Rosa‐Neto11Serge Gauthier12McGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMoCA Clinic and Institute Neuro‐Rive‐Sud Greenfield Park Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaMcGill University Research Centre for Studies in Aging Verdun Quebec CanadaAbstract Background Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in vivo. Method Two hundred and twenty‐one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impairment, and 26 AD) underwent [18F]MK6240‐tau‐positron emission tomography (PET), [18F]AZD4694‐amyloid‐PET, magnetic resonance imaging, and neuropsychological evaluations. Spearman correlations and voxel‐based regression models evaluated the relationship between Neuropsychiatric Inventory Questionnaire (NPI‐Q) scores, and tau‐PET, amyloid‐PET, and voxel‐based morphometry. Results Fifty percent of individuals presented NPS; these correlated with tau, not amyloid beta or neurodegeneration. Associations between NPI‐Q score and tau‐PET were stronger in the parietal association area, superior frontal, temporal, and medial occipital lobes. NPI‐Q domains associated with distinct patterns of tau uptake. Conclusions NPS are predominantly related to tau in aging and dementia. Regions affected are part of the behavioral circuits, and vulnerable to early AD pathology. Domain‐specific analyses showed NPS are related to the AD pathophysiological processes in a symptom‐specific manner.https://doi.org/10.1002/trc2.12154Alzheimer's diseaseamyloid betaneurodegenerationneuropsychiatric symptomstau |
| spellingShingle | Cécile Tissot Joseph Therriault Tharick A. Pascoal Mira Chamoun Firoza Z. Lussier Melissa Savard Sulantha S. Mathotaarachchi Andréa L. Benedet Emilie M. Thomas Marlee Parsons Ziad Nasreddine Pedro Rosa‐Neto Serge Gauthier Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease amyloid beta neurodegeneration neuropsychiatric symptoms tau |
| title | Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease |
| title_full | Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease |
| title_fullStr | Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease |
| title_full_unstemmed | Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease |
| title_short | Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease |
| title_sort | association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to alzheimer s disease |
| topic | Alzheimer's disease amyloid beta neurodegeneration neuropsychiatric symptoms tau |
| url | https://doi.org/10.1002/trc2.12154 |
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