Optimal management of sarcopenia
Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-08-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/optimal-management-of-sarcopenia-peer-reviewed-article-CIA |
| _version_ | 1819195533712949248 |
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| author | Louise A Burton Deepa Sumukadas |
| author_facet | Louise A Burton Deepa Sumukadas |
| author_sort | Louise A Burton |
| collection | DOAJ |
| description | Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of sarcopenia, and thereby reduce the age-related decline and disability. This paper reviews (1) the mechanisms of sarcopenia, (2) the diagnosis of sarcopenia, and (3) the potential interventions for ­sarcopenia. Multiple factors appear to be involved in the development of sarcopenia including the loss of muscle mass and muscle fibers, increased inflammation, altered hormonal levels, poor ­nutritional status, and altered renin–angiotensin system. The lack of diagnostic criteria to identify patients with sarcopenia hinders potential management options. To date, ­pharmacological ­interventions have shown limited efficacy in counteracting the effects of sarcopenia. Recent evidence has shown benefits with angiotensin-converting enzyme inhibitors; however, further randomized controlled trials are required. Resistance training remains the most effective intervention for sarcopenia; however, older people maybe unable or unwilling to embark on strenuous exercise training programs.Keywords: aged, muscle function, sarcopenia |
| first_indexed | 2024-12-23T02:14:17Z |
| format | Article |
| id | doaj.art-c6f421a3ab1a41c685150851a47e23e0 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-23T02:14:17Z |
| publishDate | 2010-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-c6f421a3ab1a41c685150851a47e23e02022-12-21T18:03:42ZengDove Medical PressClinical Interventions in Aging1178-19982010-08-01Volume 52172285028Optimal management of sarcopeniaLouise A BurtonDeepa SumukadasLouise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of sarcopenia, and thereby reduce the age-related decline and disability. This paper reviews (1) the mechanisms of sarcopenia, (2) the diagnosis of sarcopenia, and (3) the potential interventions for ­sarcopenia. Multiple factors appear to be involved in the development of sarcopenia including the loss of muscle mass and muscle fibers, increased inflammation, altered hormonal levels, poor ­nutritional status, and altered renin–angiotensin system. The lack of diagnostic criteria to identify patients with sarcopenia hinders potential management options. To date, ­pharmacological ­interventions have shown limited efficacy in counteracting the effects of sarcopenia. Recent evidence has shown benefits with angiotensin-converting enzyme inhibitors; however, further randomized controlled trials are required. Resistance training remains the most effective intervention for sarcopenia; however, older people maybe unable or unwilling to embark on strenuous exercise training programs.Keywords: aged, muscle function, sarcopeniahttps://www.dovepress.com/optimal-management-of-sarcopenia-peer-reviewed-article-CIAsarcopeniaagedphysical function |
| spellingShingle | Louise A Burton Deepa Sumukadas Optimal management of sarcopenia Clinical Interventions in Aging sarcopenia aged physical function |
| title | Optimal management of sarcopenia |
| title_full | Optimal management of sarcopenia |
| title_fullStr | Optimal management of sarcopenia |
| title_full_unstemmed | Optimal management of sarcopenia |
| title_short | Optimal management of sarcopenia |
| title_sort | optimal management of sarcopenia |
| topic | sarcopenia aged physical function |
| url | https://www.dovepress.com/optimal-management-of-sarcopenia-peer-reviewed-article-CIA |
| work_keys_str_mv | AT louiseaburton optimalmanagementofsarcopenia AT deepasumukadas optimalmanagementofsarcopenia |