Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients
Abstract Background Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been s...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-023-03259-2 |
| _version_ | 1797779006556209152 |
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| author | Win Hlaing Than Gordon Chun-Kau Chan Bonnie Ching-Ha Kwan Ka-Bik Lai Ronald Cheong-Kin Chan Jeromy Yuen Chun Teoh Jack Kit-Chung Ng Winston Wing-Shing Fung Kai-Ming Chow Phyllis Mei-Shan Cheng Philip Kam-Tao Li Cheuk-Chun Szeto |
| author_facet | Win Hlaing Than Gordon Chun-Kau Chan Bonnie Ching-Ha Kwan Ka-Bik Lai Ronald Cheong-Kin Chan Jeromy Yuen Chun Teoh Jack Kit-Chung Ng Winston Wing-Shing Fung Kai-Ming Chow Phyllis Mei-Shan Cheng Philip Kam-Tao Li Cheuk-Chun Szeto |
| author_sort | Win Hlaing Than |
| collection | DOAJ |
| description | Abstract Background Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. Methods We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. Results The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p < 0.001). In nondiabetic patients, plasma vaspin level quartile was an independent predictor of patient survival after adjusting for confounding clinical factors (adjusted hazard ratio 2.038, 95% confidence interval 1.191–3.487, p = 0.009), while the result for diabetic patients was not significant. Conclusions Plasma vaspin level quartile had a significant association with patient survival in non-diabetic PD patients. Baseline plasma vaspin level also had a modest inverse correlation with the subsequent change in the severity of insulin resistance, but the exact biological role of vaspin deserves further studies. |
| first_indexed | 2024-03-12T23:25:32Z |
| format | Article |
| id | doaj.art-c6f6b9095fcb4dc2b617fcfeefd5d6e0 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-03-12T23:25:32Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-c6f6b9095fcb4dc2b617fcfeefd5d6e02023-07-16T11:11:54ZengBMCBMC Nephrology1471-23692023-07-012411910.1186/s12882-023-03259-2Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patientsWin Hlaing Than0Gordon Chun-Kau Chan1Bonnie Ching-Ha Kwan2Ka-Bik Lai3Ronald Cheong-Kin Chan4Jeromy Yuen Chun Teoh5Jack Kit-Chung Ng6Winston Wing-Shing Fung7Kai-Ming Chow8Phyllis Mei-Shan Cheng9Philip Kam-Tao Li10Cheuk-Chun Szeto11Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Medicine & Therapeutics, Prince of Wales HospitalCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong KongCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Anatomical & Cellular Pathology, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDepartment of Medicine & Therapeutics, Prince of Wales HospitalDepartment of Medicine & Therapeutics, Prince of Wales HospitalDepartment of Medicine & Therapeutics, Prince of Wales HospitalCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Medicine & Therapeutics, Prince of Wales HospitalCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong KongAbstract Background Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. Methods We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. Results The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p < 0.001). In nondiabetic patients, plasma vaspin level quartile was an independent predictor of patient survival after adjusting for confounding clinical factors (adjusted hazard ratio 2.038, 95% confidence interval 1.191–3.487, p = 0.009), while the result for diabetic patients was not significant. Conclusions Plasma vaspin level quartile had a significant association with patient survival in non-diabetic PD patients. Baseline plasma vaspin level also had a modest inverse correlation with the subsequent change in the severity of insulin resistance, but the exact biological role of vaspin deserves further studies.https://doi.org/10.1186/s12882-023-03259-2Renal failureAtherosclerosisMetabolic syndrome |
| spellingShingle | Win Hlaing Than Gordon Chun-Kau Chan Bonnie Ching-Ha Kwan Ka-Bik Lai Ronald Cheong-Kin Chan Jeromy Yuen Chun Teoh Jack Kit-Chung Ng Winston Wing-Shing Fung Kai-Ming Chow Phyllis Mei-Shan Cheng Philip Kam-Tao Li Cheuk-Chun Szeto Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients BMC Nephrology Renal failure Atherosclerosis Metabolic syndrome |
| title | Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients |
| title_full | Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients |
| title_fullStr | Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients |
| title_full_unstemmed | Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients |
| title_short | Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients |
| title_sort | plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients |
| topic | Renal failure Atherosclerosis Metabolic syndrome |
| url | https://doi.org/10.1186/s12882-023-03259-2 |
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