Viscocapillary instability in cellular spheroids
We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular spheroids. In the condition where the cells constituting the spheroid get their necessary metabolites from the immediate, outer microenvironment, a permanent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2021-01-01
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| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/abe9d6 |
| _version_ | 1797750168470159360 |
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| author | Matthieu Martin Thomas Risler |
| author_facet | Matthieu Martin Thomas Risler |
| author_sort | Matthieu Martin |
| collection | DOAJ |
| description | We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular spheroids. In the condition where the cells constituting the spheroid get their necessary metabolites from the immediate, outer microenvironment, a permanent cell flow exists within the spheroid from its outer rim where cells divide towards its core where they die. A perturbation of the spherical symmetry induces viscous shear stresses within the tissue that can destabilise the aggregate. The proposed instability is viscocapillary in nature and does not rely on external heterogeneities, such as a pre-existing pattern of blood vessels or the presence of a substrate on which the cells can exert pulling forces. It arises for sufficiently large cell–cell adhesion strengths, cell-renewal rates, and metabolite supplies, as described by our model parameters. Since multicellular spheroids in culture are good model systems of small, avascular tumours, mimicking the metabolite concentration gradients found in vivo , we can speculate that our description applies to microtumour instabilities in cancer progression. |
| first_indexed | 2024-03-12T16:29:47Z |
| format | Article |
| id | doaj.art-c6f7c0f6ee2a4a3c84843d9055dc6ed1 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:29:47Z |
| publishDate | 2021-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-c6f7c0f6ee2a4a3c84843d9055dc6ed12023-08-08T15:35:21ZengIOP PublishingNew Journal of Physics1367-26302021-01-0123303303210.1088/1367-2630/abe9d6Viscocapillary instability in cellular spheroidsMatthieu Martin0Thomas Risler1https://orcid.org/0000-0003-1677-4636Laboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, Sorbonne Université, CNRS , 26 rue d’Ulm, 75005 Paris, FranceLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, Sorbonne Université, CNRS , 26 rue d’Ulm, 75005 Paris, FranceWe describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular spheroids. In the condition where the cells constituting the spheroid get their necessary metabolites from the immediate, outer microenvironment, a permanent cell flow exists within the spheroid from its outer rim where cells divide towards its core where they die. A perturbation of the spherical symmetry induces viscous shear stresses within the tissue that can destabilise the aggregate. The proposed instability is viscocapillary in nature and does not rely on external heterogeneities, such as a pre-existing pattern of blood vessels or the presence of a substrate on which the cells can exert pulling forces. It arises for sufficiently large cell–cell adhesion strengths, cell-renewal rates, and metabolite supplies, as described by our model parameters. Since multicellular spheroids in culture are good model systems of small, avascular tumours, mimicking the metabolite concentration gradients found in vivo , we can speculate that our description applies to microtumour instabilities in cancer progression.https://doi.org/10.1088/1367-2630/abe9d6spheroidsviscocapillary instabilitycancerdormancy |
| spellingShingle | Matthieu Martin Thomas Risler Viscocapillary instability in cellular spheroids New Journal of Physics spheroids viscocapillary instability cancer dormancy |
| title | Viscocapillary instability in cellular spheroids |
| title_full | Viscocapillary instability in cellular spheroids |
| title_fullStr | Viscocapillary instability in cellular spheroids |
| title_full_unstemmed | Viscocapillary instability in cellular spheroids |
| title_short | Viscocapillary instability in cellular spheroids |
| title_sort | viscocapillary instability in cellular spheroids |
| topic | spheroids viscocapillary instability cancer dormancy |
| url | https://doi.org/10.1088/1367-2630/abe9d6 |
| work_keys_str_mv | AT matthieumartin viscocapillaryinstabilityincellularspheroids AT thomasrisler viscocapillaryinstabilityincellularspheroids |