High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression
<p>Abstract</p> <p>Background</p> <p>Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigate...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-10-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/9/385 |
| _version_ | 1818788386941435904 |
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| author | Oleksiewicz Martin B Ørntoft Torben F Borre Michael Fristrup Niels Bartels Annette Egerod Frederikke Brünner Nils Dyrskjøt Lars |
| author_facet | Oleksiewicz Martin B Ørntoft Torben F Borre Michael Fristrup Niels Bartels Annette Egerod Frederikke Brünner Nils Dyrskjøt Lars |
| author_sort | Oleksiewicz Martin B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression.</p> <p>Methods</p> <p>Expression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer.</p> <p>Results</p> <p>The frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer (T2-4). Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors (P = 0.001). Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 (log-rank test, P = 0.035). Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies.</p> <p>Conclusion</p> <p>The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer.</p> |
| first_indexed | 2024-12-18T14:22:51Z |
| format | Article |
| id | doaj.art-c6f83093227f493f80c2e02ff3ffba4c |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-18T14:22:51Z |
| publishDate | 2009-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-c6f83093227f493f80c2e02ff3ffba4c2022-12-21T21:04:49ZengBMCBMC Cancer1471-24072009-10-019138510.1186/1471-2407-9-385High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progressionOleksiewicz Martin BØrntoft Torben FBorre MichaelFristrup NielsBartels AnnetteEgerod FrederikkeBrünner NilsDyrskjøt Lars<p>Abstract</p> <p>Background</p> <p>Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression.</p> <p>Methods</p> <p>Expression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer.</p> <p>Results</p> <p>The frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer (T2-4). Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors (P = 0.001). Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 (log-rank test, P = 0.035). Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies.</p> <p>Conclusion</p> <p>The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer.</p>http://www.biomedcentral.com/1471-2407/9/385 |
| spellingShingle | Oleksiewicz Martin B Ørntoft Torben F Borre Michael Fristrup Niels Bartels Annette Egerod Frederikke Brünner Nils Dyrskjøt Lars High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression BMC Cancer |
| title | High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression |
| title_full | High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression |
| title_fullStr | High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression |
| title_full_unstemmed | High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression |
| title_short | High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression |
| title_sort | high frequency of tumor cells with nuclear egr 1 protein expression in human bladder cancer is associated with disease progression |
| url | http://www.biomedcentral.com/1471-2407/9/385 |
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