Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions
Bone-forming cells or osteoblasts play an important role in bone modeling and remodeling processes. Osteoblast differentiation or osteoblastogenesis is orchestrated by multiple intracellular signaling pathways (e.g., bone morphogenetic proteins (BMP) and Wnt signaling pathways) and is modulated by t...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/19/10459 |
| _version_ | 1797516365849952256 |
|---|---|
| author | Hiroaki Kito Susumu Ohya |
| author_facet | Hiroaki Kito Susumu Ohya |
| author_sort | Hiroaki Kito |
| collection | DOAJ |
| description | Bone-forming cells or osteoblasts play an important role in bone modeling and remodeling processes. Osteoblast differentiation or osteoblastogenesis is orchestrated by multiple intracellular signaling pathways (e.g., bone morphogenetic proteins (BMP) and Wnt signaling pathways) and is modulated by the extracellular environment (e.g., parathyroid hormone (PTH), vitamin D, transforming growth factor β (TGF-β), and integrins). The regulation of bone homeostasis depends on the proper differentiation and function of osteoblast lineage cells from osteogenic precursors to osteocytes. Intracellular Ca<sup>2+</sup> signaling relies on the control of numerous processes in osteoblast lineage cells, including cell growth, differentiation, migration, and gene expression. In addition, hyperpolarization via the activation of K<sup>+</sup> channels indirectly promotes Ca<sup>2+</sup> signaling in osteoblast lineage cells. An improved understanding of the fundamental physiological and pathophysiological processes in bone homeostasis requires detailed investigations of osteoblast lineage cells. This review summarizes the current knowledge on the functional impacts of K<sup>+</sup> channels and Ca<sup>2+</sup>-permeable channels, which critically regulate Ca<sup>2+</sup> signaling in osteoblast lineage cells to maintain bone homeostasis. |
| first_indexed | 2024-03-10T07:00:13Z |
| format | Article |
| id | doaj.art-c6f86b4ed1b740e7bfccf9f394d8600a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:00:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c6f86b4ed1b740e7bfccf9f394d8600a2023-11-22T16:10:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191045910.3390/ijms221910459Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast FunctionsHiroaki Kito0Susumu Ohya1Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanBone-forming cells or osteoblasts play an important role in bone modeling and remodeling processes. Osteoblast differentiation or osteoblastogenesis is orchestrated by multiple intracellular signaling pathways (e.g., bone morphogenetic proteins (BMP) and Wnt signaling pathways) and is modulated by the extracellular environment (e.g., parathyroid hormone (PTH), vitamin D, transforming growth factor β (TGF-β), and integrins). The regulation of bone homeostasis depends on the proper differentiation and function of osteoblast lineage cells from osteogenic precursors to osteocytes. Intracellular Ca<sup>2+</sup> signaling relies on the control of numerous processes in osteoblast lineage cells, including cell growth, differentiation, migration, and gene expression. In addition, hyperpolarization via the activation of K<sup>+</sup> channels indirectly promotes Ca<sup>2+</sup> signaling in osteoblast lineage cells. An improved understanding of the fundamental physiological and pathophysiological processes in bone homeostasis requires detailed investigations of osteoblast lineage cells. This review summarizes the current knowledge on the functional impacts of K<sup>+</sup> channels and Ca<sup>2+</sup>-permeable channels, which critically regulate Ca<sup>2+</sup> signaling in osteoblast lineage cells to maintain bone homeostasis.https://www.mdpi.com/1422-0067/22/19/10459osteoblast lineage cellK<sup>+</sup> channelCa<sup>2+</sup>-permeable channelproliferationdifferentiationosteoblastogenesis |
| spellingShingle | Hiroaki Kito Susumu Ohya Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions International Journal of Molecular Sciences osteoblast lineage cell K<sup>+</sup> channel Ca<sup>2+</sup>-permeable channel proliferation differentiation osteoblastogenesis |
| title | Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions |
| title_full | Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions |
| title_fullStr | Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions |
| title_full_unstemmed | Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions |
| title_short | Role of K<sup>+</sup> and Ca<sup>2+</sup>-Permeable Channels in Osteoblast Functions |
| title_sort | role of k sup sup and ca sup 2 sup permeable channels in osteoblast functions |
| topic | osteoblast lineage cell K<sup>+</sup> channel Ca<sup>2+</sup>-permeable channel proliferation differentiation osteoblastogenesis |
| url | https://www.mdpi.com/1422-0067/22/19/10459 |
| work_keys_str_mv | AT hiroakikito roleofksupsupandcasup2suppermeablechannelsinosteoblastfunctions AT susumuohya roleofksupsupandcasup2suppermeablechannelsinosteoblastfunctions |