Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts.
<h4>Aims</h4>The incidence and mortality of hepatocellular carcinoma (HCC) have decreased over time in South Korea, where hepatitis B virus (HBV) in endemic. This study investigated the changes in the characteristics and clinical outcomes of HCC patients in Korea.<h4>Methods</h4...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0265668 |
| _version_ | 1818029559317004288 |
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| author | Sang Il Choi Yuri Cho Moran Ki Bo Hyun Kim In Joon Lee Tae Hyun Kim Seong Hoon Kim Young Hwan Koh Hyun Beom Kim Eun Kyung Hong Chang-Min Kim Joong-Won Park |
| author_facet | Sang Il Choi Yuri Cho Moran Ki Bo Hyun Kim In Joon Lee Tae Hyun Kim Seong Hoon Kim Young Hwan Koh Hyun Beom Kim Eun Kyung Hong Chang-Min Kim Joong-Won Park |
| author_sort | Sang Il Choi |
| collection | DOAJ |
| description | <h4>Aims</h4>The incidence and mortality of hepatocellular carcinoma (HCC) have decreased over time in South Korea, where hepatitis B virus (HBV) in endemic. This study investigated the changes in the characteristics and clinical outcomes of HCC patients in Korea.<h4>Methods</h4>Patients initially diagnosed with HCC and treated at the National Cancer Center, Korea between 2000 and 2015 (n = 4,291) were followed up until February 2017. Differences in patient characteristics and outcomes were compared between chronological cohorts: cohort A (2000-2004, n = 1,157) vs. B (2005-2009, n = 1,678) vs. C (2010-2015, n = 1,456).<h4>Results</h4>The median age of the patient cohort was 57 years (range, 13-98 years), and male predominance was noted (81.6%). HBV infection was the most common etiology (74.8%). The proportion of patients diagnosed with good liver function and small tumors (<2 cm) increased significantly over time: 74.6%, 79.9%, and 87.4% for Child-Pugh class A (p<0.001) and 8.0%, 8.5%, and 12.0% for modified UICC stage I (p<0.001) in cohorts A, B, and C, respectively. Median overall survival improved significantly over time: 14.4 months (95% confidence interval [CI], 12.0-16.8 months), 22.9 months (95% CI, 20.3-25.5 months), and 53.6 months (95% CI, 45.7-61.5 months) in cohorts A, B, and C, respectively. HBV-related patients showed significantly improved survival (12.7 vs. 20.4 vs. 64.5 months, p<0.001) associated with the use of antiviral treatments (adjusted hazard ratio, 0.72; 95% CI, 0.64-0.80).<h4>Conclusions</h4>The survival of patients with HCC, especially HBV-related HCC, has improved significantly over time in Korea. |
| first_indexed | 2024-12-10T05:21:37Z |
| format | Article |
| id | doaj.art-c6f89cabdd9240859484d4b34182e160 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T05:21:37Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c6f89cabdd9240859484d4b34182e1602022-12-22T02:00:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026566810.1371/journal.pone.0265668Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts.Sang Il ChoiYuri ChoMoran KiBo Hyun KimIn Joon LeeTae Hyun KimSeong Hoon KimYoung Hwan KohHyun Beom KimEun Kyung HongChang-Min KimJoong-Won Park<h4>Aims</h4>The incidence and mortality of hepatocellular carcinoma (HCC) have decreased over time in South Korea, where hepatitis B virus (HBV) in endemic. This study investigated the changes in the characteristics and clinical outcomes of HCC patients in Korea.<h4>Methods</h4>Patients initially diagnosed with HCC and treated at the National Cancer Center, Korea between 2000 and 2015 (n = 4,291) were followed up until February 2017. Differences in patient characteristics and outcomes were compared between chronological cohorts: cohort A (2000-2004, n = 1,157) vs. B (2005-2009, n = 1,678) vs. C (2010-2015, n = 1,456).<h4>Results</h4>The median age of the patient cohort was 57 years (range, 13-98 years), and male predominance was noted (81.6%). HBV infection was the most common etiology (74.8%). The proportion of patients diagnosed with good liver function and small tumors (<2 cm) increased significantly over time: 74.6%, 79.9%, and 87.4% for Child-Pugh class A (p<0.001) and 8.0%, 8.5%, and 12.0% for modified UICC stage I (p<0.001) in cohorts A, B, and C, respectively. Median overall survival improved significantly over time: 14.4 months (95% confidence interval [CI], 12.0-16.8 months), 22.9 months (95% CI, 20.3-25.5 months), and 53.6 months (95% CI, 45.7-61.5 months) in cohorts A, B, and C, respectively. HBV-related patients showed significantly improved survival (12.7 vs. 20.4 vs. 64.5 months, p<0.001) associated with the use of antiviral treatments (adjusted hazard ratio, 0.72; 95% CI, 0.64-0.80).<h4>Conclusions</h4>The survival of patients with HCC, especially HBV-related HCC, has improved significantly over time in Korea.https://doi.org/10.1371/journal.pone.0265668 |
| spellingShingle | Sang Il Choi Yuri Cho Moran Ki Bo Hyun Kim In Joon Lee Tae Hyun Kim Seong Hoon Kim Young Hwan Koh Hyun Beom Kim Eun Kyung Hong Chang-Min Kim Joong-Won Park Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts. PLoS ONE |
| title | Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts. |
| title_full | Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts. |
| title_fullStr | Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts. |
| title_full_unstemmed | Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts. |
| title_short | Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts. |
| title_sort | better survival of patients with hepatitis b virus related hepatocellular carcinoma in south korea changes in 16 years cohorts |
| url | https://doi.org/10.1371/journal.pone.0265668 |
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