Host cell protein quantification workflow using optimized standards combined with data-independent acquisition mass spectrometry

Host cell protein quantification workflow using optimized standards combined with data-independent acquisition mass spectrometry

Monitoring of host cell proteins (HCPs) during the manufacturing of monoclonal antibodies (mAb) has become a critical requirement to provide effective and safe drug products. Enzyme-linked immunosorbent assays are still the gold standard methods for the quantification of protein impurities. However,...

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Bibliographic Details
Main Authors: Steve Hessmann, Cyrille Chery, Anne-Sophie Sikora, Annick Gervais, Christine Carapito
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Host cell proteins
Absolute quantification standards
Data-independent acquisition
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923000606

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